Does METHOTREXATE Cause Angioedema? 423 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 423 reports of Angioedema have been filed in association with METHOTREXATE (Methotrexate). This represents 0.2% of all adverse event reports for METHOTREXATE.
423
Reports of Angioedema with METHOTREXATE
0.2%
of all METHOTREXATE reports
1
Deaths
88
Hospitalizations
How Dangerous Is Angioedema From METHOTREXATE?
Of the 423 reports, 1 (0.2%) resulted in death, 88 (20.8%) required hospitalization, and 33 (7.8%) were considered life-threatening.
Is Angioedema Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for METHOTREXATE. However, 423 reports have been filed with the FAERS database.
What Other Side Effects Does METHOTREXATE Cause?
Drug ineffective (70,142)
Rheumatoid arthritis (29,254)
Off label use (24,020)
Pain (23,773)
Drug intolerance (22,555)
Arthralgia (21,831)
Fatigue (19,885)
Nausea (18,715)
Joint swelling (17,657)
Drug hypersensitivity (16,677)
What Other Drugs Cause Angioedema?
LISINOPRIL (5,370)
IBUPROFEN (2,507)
OMALIZUMAB (1,650)
ACETAMINOPHEN (1,152)
RAMIPRIL (1,130)
AMOXICILLIN (943)
ASPIRIN (820)
CETIRIZINE (766)
DICLOFENAC (766)
SACUBITRIL\VALSARTAN (730)
Which METHOTREXATE Alternatives Have Lower Angioedema Risk?
METHOTREXATE vs METHOXSALEN
METHOTREXATE vs METHOXY POLYETHYLENE GLYCOL-EPOETIN BETA
METHOTREXATE vs METHYL ALCOHOL
METHOTREXATE vs METHYLCOBALAMIN
METHOTREXATE vs METHYLDOPA