Does METHOTREXATE Cause Bone marrow failure? 1,401 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 1,401 reports of Bone marrow failure have been filed in association with METHOTREXATE (Methotrexate). This represents 0.6% of all adverse event reports for METHOTREXATE.
1,401
Reports of Bone marrow failure with METHOTREXATE
0.6%
of all METHOTREXATE reports
374
Deaths
783
Hospitalizations
How Dangerous Is Bone marrow failure From METHOTREXATE?
Of the 1,401 reports, 374 (26.7%) resulted in death, 783 (55.9%) required hospitalization, and 254 (18.1%) were considered life-threatening.
Is Bone marrow failure Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for METHOTREXATE. However, 1,401 reports have been filed with the FAERS database.
What Other Side Effects Does METHOTREXATE Cause?
Drug ineffective (70,142)
Rheumatoid arthritis (29,254)
Off label use (24,020)
Pain (23,773)
Drug intolerance (22,555)
Arthralgia (21,831)
Fatigue (19,885)
Nausea (18,715)
Joint swelling (17,657)
Drug hypersensitivity (16,677)
What Other Drugs Cause Bone marrow failure?
CYCLOPHOSPHAMIDE (1,834)
ETOPOSIDE (1,081)
RITUXIMAB (1,060)
CYTARABINE (1,052)
VINCRISTINE (1,001)
DOXORUBICIN (1,000)
PALBOCICLIB (951)
CARBOPLATIN (855)
BEVACIZUMAB (835)
DEXAMETHASONE (727)
Which METHOTREXATE Alternatives Have Lower Bone marrow failure Risk?
METHOTREXATE vs METHOXSALEN
METHOTREXATE vs METHOXY POLYETHYLENE GLYCOL-EPOETIN BETA
METHOTREXATE vs METHYL ALCOHOL
METHOTREXATE vs METHYLCOBALAMIN
METHOTREXATE vs METHYLDOPA