Does METHOTREXATE Cause Clostridium difficile colitis? 562 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 562 reports of Clostridium difficile colitis have been filed in association with METHOTREXATE (Methotrexate). This represents 0.2% of all adverse event reports for METHOTREXATE.
562
Reports of Clostridium difficile colitis with METHOTREXATE
0.2%
of all METHOTREXATE reports
263
Deaths
212
Hospitalizations
How Dangerous Is Clostridium difficile colitis From METHOTREXATE?
Of the 562 reports, 263 (46.8%) resulted in death, 212 (37.7%) required hospitalization, and 52 (9.3%) were considered life-threatening.
Is Clostridium difficile colitis Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for METHOTREXATE. However, 562 reports have been filed with the FAERS database.
What Other Side Effects Does METHOTREXATE Cause?
Drug ineffective (70,142)
Rheumatoid arthritis (29,254)
Off label use (24,020)
Pain (23,773)
Drug intolerance (22,555)
Arthralgia (21,831)
Fatigue (19,885)
Nausea (18,715)
Joint swelling (17,657)
Drug hypersensitivity (16,677)
What Other Drugs Cause Clostridium difficile colitis?
CYCLOPHOSPHAMIDE (717)
PREDNISONE (619)
DEXAMETHASONE (575)
ETOPOSIDE (503)
CYTARABINE (489)
VINCRISTINE (482)
LENALIDOMIDE (388)
METHYLPREDNISOLONE (385)
CIPROFLOXACIN (378)
TACROLIMUS (346)
Which METHOTREXATE Alternatives Have Lower Clostridium difficile colitis Risk?
METHOTREXATE vs METHOXSALEN
METHOTREXATE vs METHOXY POLYETHYLENE GLYCOL-EPOETIN BETA
METHOTREXATE vs METHYL ALCOHOL
METHOTREXATE vs METHYLCOBALAMIN
METHOTREXATE vs METHYLDOPA