Clostridium difficile colitis: Which Medications Cause It? (7,539 Reports Across 515 Drugs)
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Clostridium difficile colitis has been reported as an adverse event with 515 different drugs in the FDA's FAERS database, with 7,539 total reports. 1,377 of these reports resulted in death.The drugs most commonly associated with Clostridium difficile colitis are CYCLOPHOSPHAMIDE, PREDNISONE, and DEXAMETHASONE.
7,539
Total Reports
515
Drugs Involved
1,377
Deaths
5,112
Hospitalizations
57.4 yrs
Average Patient Age
55.1% / 44.9%
Female / Male
Which Drugs Cause Clostridium difficile colitis Most Often?
| Drug | Reports | % of Drug Reports | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| CYCLOPHOSPHAMIDE | 717 | 0.6% | 291 | 332 | 62 |
| PREDNISONE | 619 | 0.4% | 316 | 278 | 78 |
| DEXAMETHASONE | 575 | 0.5% | 268 | 296 | 55 |
| METHOTREXATE | 562 | 0.2% | 263 | 212 | 52 |
| ETOPOSIDE | 503 | 1.0% | 235 | 189 | 35 |
| CYTARABINE | 489 | 1.1% | 258 | 206 | 36 |
| VINCRISTINE | 482 | 0.7% | 245 | 174 | 49 |
| LENALIDOMIDE | 388 | 0.1% | 46 | 226 | 18 |
| METHYLPREDNISOLONE | 385 | 0.6% | 253 | 105 | 39 |
| CIPROFLOXACIN | 378 | 0.9% | 94 | 323 | 38 |
| TACROLIMUS | 346 | 0.4% | 83 | 219 | 73 |
| DAUNORUBICIN | 331 | 3.4% | 218 | 116 | 8 |
| VANCOMYCIN | 329 | 1.0% | 84 | 204 | 25 |
| FILGRASTIM | 321 | 2.2% | 209 | 100 | 3 |
| METRONIDAZOLE | 312 | 1.4% | 69 | 206 | 32 |
| PIPERACILLIN\TAZOBACTAM | 306 | 1.6% | 51 | 247 | 40 |
| MYCOPHENOLATE MOFETIL | 283 | 0.4% | 71 | 153 | 29 |
| CYCLOSPORINE | 275 | 0.4% | 115 | 129 | 5 |
| RITUXIMAB | 274 | 0.2% | 55 | 131 | 31 |
| CEFTRIAXONE | 268 | 1.4% | 49 | 214 | 19 |