Does METHOTREXATE Cause Clostridium difficile infection? 588 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 588 reports of Clostridium difficile infection have been filed in association with METHOTREXATE (Methotrexate). This represents 0.2% of all adverse event reports for METHOTREXATE.
588
Reports of Clostridium difficile infection with METHOTREXATE
0.2%
of all METHOTREXATE reports
60
Deaths
354
Hospitalizations
How Dangerous Is Clostridium difficile infection From METHOTREXATE?
Of the 588 reports, 60 (10.2%) resulted in death, 354 (60.2%) required hospitalization, and 42 (7.1%) were considered life-threatening.
Is Clostridium difficile infection Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for METHOTREXATE. However, 588 reports have been filed with the FAERS database.
What Other Side Effects Does METHOTREXATE Cause?
Drug ineffective (70,142)
Rheumatoid arthritis (29,254)
Off label use (24,020)
Pain (23,773)
Drug intolerance (22,555)
Arthralgia (21,831)
Fatigue (19,885)
Nausea (18,715)
Joint swelling (17,657)
Drug hypersensitivity (16,677)
What Other Drugs Cause Clostridium difficile infection?
ADALIMUMAB (1,502)
INFLIXIMAB (1,419)
VEDOLIZUMAB (1,130)
LENALIDOMIDE (814)
VANCOMYCIN (743)
METRONIDAZOLE (619)
PREDNISONE (618)
RITUXIMAB (532)
CIPROFLOXACIN (508)
CYCLOPHOSPHAMIDE (504)
Which METHOTREXATE Alternatives Have Lower Clostridium difficile infection Risk?
METHOTREXATE vs METHOXSALEN
METHOTREXATE vs METHOXY POLYETHYLENE GLYCOL-EPOETIN BETA
METHOTREXATE vs METHYL ALCOHOL
METHOTREXATE vs METHYLCOBALAMIN
METHOTREXATE vs METHYLDOPA