Does METHOTREXATE Cause Epilepsy? 960 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 960 reports of Epilepsy have been filed in association with METHOTREXATE (Methotrexate). This represents 0.4% of all adverse event reports for METHOTREXATE.
960
Reports of Epilepsy with METHOTREXATE
0.4%
of all METHOTREXATE reports
648
Deaths
686
Hospitalizations
How Dangerous Is Epilepsy From METHOTREXATE?
Of the 960 reports, 648 (67.5%) resulted in death, 686 (71.5%) required hospitalization, and 586 (61.0%) were considered life-threatening.
Is Epilepsy Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for METHOTREXATE. However, 960 reports have been filed with the FAERS database.
What Other Side Effects Does METHOTREXATE Cause?
Drug ineffective (70,142)
Rheumatoid arthritis (29,254)
Off label use (24,020)
Pain (23,773)
Drug intolerance (22,555)
Arthralgia (21,831)
Fatigue (19,885)
Nausea (18,715)
Joint swelling (17,657)
Drug hypersensitivity (16,677)
What Other Drugs Cause Epilepsy?
LEVETIRACETAM (2,546)
LAMOTRIGINE (1,758)
ADALIMUMAB (1,107)
TOPIRAMATE (1,066)
LACOSAMIDE (902)
VALPROATE (878)
CARBAMAZEPINE (869)
RITUXIMAB (846)
CETIRIZINE (837)
TRAMADOL (817)
Which METHOTREXATE Alternatives Have Lower Epilepsy Risk?
METHOTREXATE vs METHOXSALEN
METHOTREXATE vs METHOXY POLYETHYLENE GLYCOL-EPOETIN BETA
METHOTREXATE vs METHYL ALCOHOL
METHOTREXATE vs METHYLCOBALAMIN
METHOTREXATE vs METHYLDOPA