Does METHOTREXATE Cause Hepatitis? 1,835 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 1,835 reports of Hepatitis have been filed in association with METHOTREXATE (Methotrexate). This represents 0.7% of all adverse event reports for METHOTREXATE.
1,835
Reports of Hepatitis with METHOTREXATE
0.7%
of all METHOTREXATE reports
425
Deaths
736
Hospitalizations
How Dangerous Is Hepatitis From METHOTREXATE?
Of the 1,835 reports, 425 (23.2%) resulted in death, 736 (40.1%) required hospitalization, and 414 (22.6%) were considered life-threatening.
Is Hepatitis Listed in the Official Label?
Yes, Hepatitis is listed as a known adverse reaction in the official FDA drug label for METHOTREXATE.
What Other Side Effects Does METHOTREXATE Cause?
Drug ineffective (70,142)
Rheumatoid arthritis (29,254)
Off label use (24,020)
Pain (23,773)
Drug intolerance (22,555)
Arthralgia (21,831)
Fatigue (19,885)
Nausea (18,715)
Joint swelling (17,657)
Drug hypersensitivity (16,677)
What Other Drugs Cause Hepatitis?
ACETAMINOPHEN (1,450)
TOCILIZUMAB (1,184)
HYDROXYCHLOROQUINE (1,133)
ADALIMUMAB (1,096)
RITUXIMAB (1,017)
ETANERCEPT (1,013)
LEFLUNOMIDE (997)
PEMBROLIZUMAB (935)
NIVOLUMAB (930)
ABATACEPT (902)
Which METHOTREXATE Alternatives Have Lower Hepatitis Risk?
METHOTREXATE vs METHOXSALEN
METHOTREXATE vs METHOXY POLYETHYLENE GLYCOL-EPOETIN BETA
METHOTREXATE vs METHYL ALCOHOL
METHOTREXATE vs METHYLCOBALAMIN
METHOTREXATE vs METHYLDOPA