Does METHOTREXATE Cause Hepatocellular injury? 683 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 683 reports of Hepatocellular injury have been filed in association with METHOTREXATE (Methotrexate). This represents 0.3% of all adverse event reports for METHOTREXATE.
683
Reports of Hepatocellular injury with METHOTREXATE
0.3%
of all METHOTREXATE reports
13
Deaths
265
Hospitalizations
How Dangerous Is Hepatocellular injury From METHOTREXATE?
Of the 683 reports, 13 (1.9%) resulted in death, 265 (38.8%) required hospitalization, and 28 (4.1%) were considered life-threatening.
Is Hepatocellular injury Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for METHOTREXATE. However, 683 reports have been filed with the FAERS database.
What Other Side Effects Does METHOTREXATE Cause?
Drug ineffective (70,142)
Rheumatoid arthritis (29,254)
Off label use (24,020)
Pain (23,773)
Drug intolerance (22,555)
Arthralgia (21,831)
Fatigue (19,885)
Nausea (18,715)
Joint swelling (17,657)
Drug hypersensitivity (16,677)
What Other Drugs Cause Hepatocellular injury?
ACETAMINOPHEN (1,761)
ATORVASTATIN (610)
SULFAMETHOXAZOLE\TRIMETHOPRIM (415)
ENOXAPARIN (365)
TRAMADOL (349)
AMOXICILLIN (347)
ESOMEPRAZOLE (341)
PANTOPRAZOLE (340)
VINCRISTINE (306)
METHYLPREDNISOLONE (300)
Which METHOTREXATE Alternatives Have Lower Hepatocellular injury Risk?
METHOTREXATE vs METHOXSALEN
METHOTREXATE vs METHOXY POLYETHYLENE GLYCOL-EPOETIN BETA
METHOTREXATE vs METHYL ALCOHOL
METHOTREXATE vs METHYLCOBALAMIN
METHOTREXATE vs METHYLDOPA