Hepatocellular injury: Which Medications Cause It? (11,879 Reports Across 745 Drugs)
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Hepatocellular injury has been reported as an adverse event with 745 different drugs in the FDA's FAERS database, with 11,879 total reports. 592 of these reports resulted in death.The drugs most commonly associated with Hepatocellular injury are ACETAMINOPHEN, METHOTREXATE, and ATORVASTATIN.
11,879
Total Reports
745
Drugs Involved
592
Deaths
6,811
Hospitalizations
53.3 yrs
Average Patient Age
55.2% / 44.8%
Female / Male
Which Drugs Cause Hepatocellular injury Most Often?
| Drug | Reports | % of Drug Reports | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| ACETAMINOPHEN | 1,761 | 1.3% | 67 | 1,172 | 209 |
| METHOTREXATE | 683 | 0.3% | 13 | 265 | 28 |
| ATORVASTATIN | 610 | 0.8% | 37 | 415 | 56 |
| SULFAMETHOXAZOLE\TRIMETHOPRIM | 415 | 1.1% | 28 | 303 | 38 |
| ENOXAPARIN | 365 | 1.5% | 8 | 175 | 13 |
| TRAMADOL | 349 | 0.5% | 8 | 221 | 27 |
| AMOXICILLIN | 347 | 1.2% | 29 | 203 | 44 |
| ESOMEPRAZOLE | 341 | 0.5% | 18 | 262 | 11 |
| PANTOPRAZOLE | 340 | 0.4% | 10 | 229 | 29 |
| VINCRISTINE | 306 | 0.4% | 6 | 116 | 2 |
| METHYLPREDNISOLONE | 300 | 0.5% | 15 | 164 | 5 |
| PIPERACILLIN\TAZOBACTAM | 299 | 1.6% | 14 | 197 | 19 |
| AMOXICILLIN\CLAVULANATE | 278 | 1.8% | 10 | 184 | 11 |
| LEVETIRACETAM | 278 | 0.4% | 10 | 186 | 16 |
| LANSOPRAZOLE | 277 | 0.5% | 22 | 169 | 26 |
| CEFTRIAXONE | 271 | 1.4% | 34 | 171 | 18 |
| DEXAMETHASONE | 251 | 0.2% | 29 | 98 | 5 |
| RITUXIMAB | 247 | 0.1% | 9 | 133 | 7 |
| PREGABALIN | 237 | 0.2% | 9 | 143 | 19 |
| CYCLOPHOSPHAMIDE | 232 | 0.2% | 22 | 138 | 3 |