Does METHOTREXATE Cause Hepatomegaly? 276 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 276 reports of Hepatomegaly have been filed in association with METHOTREXATE (Methotrexate). This represents 0.1% of all adverse event reports for METHOTREXATE.
276
Reports of Hepatomegaly with METHOTREXATE
0.1%
of all METHOTREXATE reports
38
Deaths
127
Hospitalizations
How Dangerous Is Hepatomegaly From METHOTREXATE?
Of the 276 reports, 38 (13.8%) resulted in death, 127 (46.0%) required hospitalization, and 12 (4.3%) were considered life-threatening.
Is Hepatomegaly Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for METHOTREXATE. However, 276 reports have been filed with the FAERS database.
What Other Side Effects Does METHOTREXATE Cause?
Drug ineffective (70,142)
Rheumatoid arthritis (29,254)
Off label use (24,020)
Pain (23,773)
Drug intolerance (22,555)
Arthralgia (21,831)
Fatigue (19,885)
Nausea (18,715)
Joint swelling (17,657)
Drug hypersensitivity (16,677)
What Other Drugs Cause Hepatomegaly?
ADALIMUMAB (225)
RUXOLITINIB (213)
CYCLOPHOSPHAMIDE (170)
VINCRISTINE (136)
ACETAMINOPHEN (126)
RITUXIMAB (115)
DEXAMETHASONE (104)
PREDNISONE (101)
SECUKINUMAB (90)
OCTREOTIDE (89)
Which METHOTREXATE Alternatives Have Lower Hepatomegaly Risk?
METHOTREXATE vs METHOXSALEN
METHOTREXATE vs METHOXY POLYETHYLENE GLYCOL-EPOETIN BETA
METHOTREXATE vs METHYL ALCOHOL
METHOTREXATE vs METHYLCOBALAMIN
METHOTREXATE vs METHYLDOPA