Does METHOTREXATE Cause Hepatorenal syndrome? 27 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 27 reports of Hepatorenal syndrome have been filed in association with METHOTREXATE (Methotrexate). This represents 0.0% of all adverse event reports for METHOTREXATE.
27
Reports of Hepatorenal syndrome with METHOTREXATE
0.0%
of all METHOTREXATE reports
21
Deaths
22
Hospitalizations
How Dangerous Is Hepatorenal syndrome From METHOTREXATE?
Of the 27 reports, 21 (77.8%) resulted in death, 22 (81.5%) required hospitalization, and 13 (48.1%) were considered life-threatening.
Is Hepatorenal syndrome Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for METHOTREXATE. However, 27 reports have been filed with the FAERS database.
What Other Side Effects Does METHOTREXATE Cause?
Drug ineffective (70,142)
Rheumatoid arthritis (29,254)
Off label use (24,020)
Pain (23,773)
Drug intolerance (22,555)
Arthralgia (21,831)
Fatigue (19,885)
Nausea (18,715)
Joint swelling (17,657)
Drug hypersensitivity (16,677)
What Other Drugs Cause Hepatorenal syndrome?
RIBAVIRIN (83)
SOFOSBUVIR (65)
SPIRONOLACTONE (53)
ACETAMINOPHEN (45)
BUDESONIDE (41)
PREDNISOLONE (39)
TACROLIMUS (38)
CYCLOPHOSPHAMIDE (37)
PREDNISONE (36)
DEXAMETHASONE (33)
Which METHOTREXATE Alternatives Have Lower Hepatorenal syndrome Risk?
METHOTREXATE vs METHOXSALEN
METHOTREXATE vs METHOXY POLYETHYLENE GLYCOL-EPOETIN BETA
METHOTREXATE vs METHYL ALCOHOL
METHOTREXATE vs METHYLCOBALAMIN
METHOTREXATE vs METHYLDOPA