Hepatorenal syndrome: Which Medications Cause It? (1,075 Reports Across 152 Drugs)
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Hepatorenal syndrome has been reported as an adverse event with 152 different drugs in the FDA's FAERS database, with 1,075 total reports. 652 of these reports resulted in death.The drugs most commonly associated with Hepatorenal syndrome are RIBAVIRIN, SOFOSBUVIR, and SPIRONOLACTONE.
1,075
Total Reports
152
Drugs Involved
652
Deaths
702
Hospitalizations
58.4 yrs
Average Patient Age
36.8% / 63.2%
Female / Male
Which Drugs Cause Hepatorenal syndrome Most Often?
| Drug | Reports | % of Drug Reports | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| RIBAVIRIN | 83 | 0.2% | 39 | 61 | 19 |
| SOFOSBUVIR | 65 | 0.4% | 35 | 50 | 10 |
| SPIRONOLACTONE | 53 | 0.3% | 14 | 42 | 18 |
| ACETAMINOPHEN | 45 | 0.0% | 22 | 36 | 5 |
| BUDESONIDE | 41 | 0.2% | 23 | 23 | 22 |
| PREDNISOLONE | 39 | 0.1% | 10 | 12 | 6 |
| TACROLIMUS | 38 | 0.0% | 8 | 13 | 6 |
| CYCLOPHOSPHAMIDE | 37 | 0.0% | 21 | 21 | 4 |
| PREDNISONE | 36 | 0.0% | 25 | 26 | 10 |
| DEXAMETHASONE | 33 | 0.0% | 23 | 19 | 3 |
| MYCOPHENOLATE MOFETIL | 31 | 0.0% | 5 | 9 | 4 |
| LANSOPRAZOLE | 30 | 0.1% | 24 | 23 | 20 |
| OMBITASVIR\PARITAPREVIR\RITONAVIR | 30 | 0.7% | 16 | 24 | 8 |
| DASABUVIR | 29 | 0.7% | 14 | 24 | 7 |
| RITUXIMAB | 29 | 0.0% | 18 | 11 | 4 |
| DOXORUBICIN | 28 | 0.0% | 13 | 20 | 0 |
| CYCLOSPORINE | 27 | 0.0% | 5 | 7 | 5 |
| METHOTREXATE | 27 | 0.0% | 21 | 22 | 13 |
| ATORVASTATIN | 26 | 0.0% | 24 | 24 | 21 |
| DACLATASVIR | 26 | 0.5% | 19 | 18 | 5 |