Does METHOTREXATE Cause Hyponatraemia? 430 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 430 reports of Hyponatraemia have been filed in association with METHOTREXATE (Methotrexate). This represents 0.2% of all adverse event reports for METHOTREXATE.
430
Reports of Hyponatraemia with METHOTREXATE
0.2%
of all METHOTREXATE reports
84
Deaths
339
Hospitalizations
How Dangerous Is Hyponatraemia From METHOTREXATE?
Of the 430 reports, 84 (19.5%) resulted in death, 339 (78.8%) required hospitalization, and 69 (16.0%) were considered life-threatening.
Is Hyponatraemia Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for METHOTREXATE. However, 430 reports have been filed with the FAERS database.
What Other Side Effects Does METHOTREXATE Cause?
Drug ineffective (70,142)
Rheumatoid arthritis (29,254)
Off label use (24,020)
Pain (23,773)
Drug intolerance (22,555)
Arthralgia (21,831)
Fatigue (19,885)
Nausea (18,715)
Joint swelling (17,657)
Drug hypersensitivity (16,677)
What Other Drugs Cause Hyponatraemia?
FUROSEMIDE (3,127)
HYDROCHLOROTHIAZIDE (2,138)
OMEPRAZOLE (1,635)
LANSOPRAZOLE (1,416)
SERTRALINE (1,332)
RAMIPRIL (1,178)
SPIRONOLACTONE (1,166)
PANTOPRAZOLE (1,134)
INDAPAMIDE (976)
AMLODIPINE (879)
Which METHOTREXATE Alternatives Have Lower Hyponatraemia Risk?
METHOTREXATE vs METHOXSALEN
METHOTREXATE vs METHOXY POLYETHYLENE GLYCOL-EPOETIN BETA
METHOTREXATE vs METHYL ALCOHOL
METHOTREXATE vs METHYLCOBALAMIN
METHOTREXATE vs METHYLDOPA