Does METHOTREXATE Cause Irritability? 268 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 268 reports of Irritability have been filed in association with METHOTREXATE (Methotrexate). This represents 0.1% of all adverse event reports for METHOTREXATE.
268
Reports of Irritability with METHOTREXATE
0.1%
of all METHOTREXATE reports
18
Deaths
71
Hospitalizations
How Dangerous Is Irritability From METHOTREXATE?
Of the 268 reports, 18 (6.7%) resulted in death, 71 (26.5%) required hospitalization, and 20 (7.5%) were considered life-threatening.
Is Irritability Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for METHOTREXATE. However, 268 reports have been filed with the FAERS database.
What Other Side Effects Does METHOTREXATE Cause?
Drug ineffective (70,142)
Rheumatoid arthritis (29,254)
Off label use (24,020)
Pain (23,773)
Drug intolerance (22,555)
Arthralgia (21,831)
Fatigue (19,885)
Nausea (18,715)
Joint swelling (17,657)
Drug hypersensitivity (16,677)
What Other Drugs Cause Irritability?
DULOXETINE (3,554)
LEVOTHYROXINE (1,692)
LEVETIRACETAM (1,067)
ARIPIPRAZOLE (851)
LEVONORGESTREL (796)
RIBAVIRIN (775)
AMPHETAMINE ASPARTATE\AMPHETAMINE\DEXTROAMPHETAMINE SACCHARATE\DEXTROAMPHETAMINE (745)
PREGABALIN (736)
METHYLPHENIDATE (735)
QUETIAPINE (638)
Which METHOTREXATE Alternatives Have Lower Irritability Risk?
METHOTREXATE vs METHOXSALEN
METHOTREXATE vs METHOXY POLYETHYLENE GLYCOL-EPOETIN BETA
METHOTREXATE vs METHYL ALCOHOL
METHOTREXATE vs METHYLCOBALAMIN
METHOTREXATE vs METHYLDOPA