Does METHOTREXATE Cause Osteoporosis? 2,018 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 2,018 reports of Osteoporosis have been filed in association with METHOTREXATE (Methotrexate). This represents 0.8% of all adverse event reports for METHOTREXATE.
2,018
Reports of Osteoporosis with METHOTREXATE
0.8%
of all METHOTREXATE reports
466
Deaths
823
Hospitalizations
How Dangerous Is Osteoporosis From METHOTREXATE?
Of the 2,018 reports, 466 (23.1%) resulted in death, 823 (40.8%) required hospitalization, and 360 (17.8%) were considered life-threatening.
Is Osteoporosis Listed in the Official Label?
Yes, Osteoporosis is listed as a known adverse reaction in the official FDA drug label for METHOTREXATE.
What Other Side Effects Does METHOTREXATE Cause?
Drug ineffective (70,142)
Rheumatoid arthritis (29,254)
Off label use (24,020)
Pain (23,773)
Drug intolerance (22,555)
Arthralgia (21,831)
Fatigue (19,885)
Nausea (18,715)
Joint swelling (17,657)
Drug hypersensitivity (16,677)
What Other Drugs Cause Osteoporosis?
EMTRICITABINE\TENOFOVIR DISOPROXIL (7,436)
TENOFOVIR DISOPROXIL (5,302)
EFAVIRENZ\EMTRICITABINE\TENOFOVIR DISOPROXIL (4,029)
ADALIMUMAB (2,665)
PREDNISONE (2,476)
ETANERCEPT (1,766)
COBICISTAT\ELVITEGRAVIR\EMTRICITABINE\TENOFOVIR DISOPROXIL (1,720)
TOCILIZUMAB (1,689)
ALENDRONATE (1,688)
ABATACEPT (1,467)
Which METHOTREXATE Alternatives Have Lower Osteoporosis Risk?
METHOTREXATE vs METHOXSALEN
METHOTREXATE vs METHOXY POLYETHYLENE GLYCOL-EPOETIN BETA
METHOTREXATE vs METHYL ALCOHOL
METHOTREXATE vs METHYLCOBALAMIN
METHOTREXATE vs METHYLDOPA