Does METHOTREXATE Cause Progressive multifocal leukoencephalopathy? 428 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 428 reports of Progressive multifocal leukoencephalopathy have been filed in association with METHOTREXATE (Methotrexate). This represents 0.2% of all adverse event reports for METHOTREXATE.
428
Reports of Progressive multifocal leukoencephalopathy with METHOTREXATE
0.2%
of all METHOTREXATE reports
193
Deaths
199
Hospitalizations
How Dangerous Is Progressive multifocal leukoencephalopathy From METHOTREXATE?
Of the 428 reports, 193 (45.1%) resulted in death, 199 (46.5%) required hospitalization, and 48 (11.2%) were considered life-threatening.
Is Progressive multifocal leukoencephalopathy Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for METHOTREXATE. However, 428 reports have been filed with the FAERS database.
What Other Side Effects Does METHOTREXATE Cause?
Drug ineffective (70,142)
Rheumatoid arthritis (29,254)
Off label use (24,020)
Pain (23,773)
Drug intolerance (22,555)
Arthralgia (21,831)
Fatigue (19,885)
Nausea (18,715)
Joint swelling (17,657)
Drug hypersensitivity (16,677)
What Other Drugs Cause Progressive multifocal leukoencephalopathy?
NATALIZUMAB (1,668)
RITUXIMAB (1,647)
CYCLOPHOSPHAMIDE (782)
PREDNISONE (606)
PREDNISOLONE (439)
TACROLIMUS (438)
DOXORUBICIN (421)
MYCOPHENOLATE MOFETIL (414)
VINCRISTINE (376)
BENDAMUSTINE (342)
Which METHOTREXATE Alternatives Have Lower Progressive multifocal leukoencephalopathy Risk?
METHOTREXATE vs METHOXSALEN
METHOTREXATE vs METHOXY POLYETHYLENE GLYCOL-EPOETIN BETA
METHOTREXATE vs METHYL ALCOHOL
METHOTREXATE vs METHYLCOBALAMIN
METHOTREXATE vs METHYLDOPA