Progressive multifocal leukoencephalopathy: Which Medications Cause It? (6,144 Reports Across 214 Drugs)
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Progressive multifocal leukoencephalopathy has been reported as an adverse event with 214 different drugs in the FDA's FAERS database, with 6,144 total reports. 1,834 of these reports resulted in death.The drugs most commonly associated with Progressive multifocal leukoencephalopathy are NATALIZUMAB, RITUXIMAB, and CYCLOPHOSPHAMIDE.
6,144
Total Reports
214
Drugs Involved
1,834
Deaths
3,121
Hospitalizations
54.2 yrs
Average Patient Age
58.1% / 41.9%
Female / Male
Which Drugs Cause Progressive multifocal leukoencephalopathy Most Often?
| Drug | Reports | % of Drug Reports | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| NATALIZUMAB | 1,668 | 2.6% | 279 | 1,201 | 140 |
| RITUXIMAB | 1,647 | 0.9% | 685 | 526 | 203 |
| CYCLOPHOSPHAMIDE | 782 | 0.6% | 395 | 310 | 87 |
| PREDNISONE | 606 | 0.4% | 278 | 250 | 103 |
| PREDNISOLONE | 439 | 0.5% | 173 | 231 | 69 |
| TACROLIMUS | 438 | 0.5% | 189 | 222 | 51 |
| METHOTREXATE | 428 | 0.2% | 193 | 199 | 48 |
| DOXORUBICIN | 421 | 0.5% | 204 | 156 | 56 |
| MYCOPHENOLATE MOFETIL | 414 | 0.6% | 168 | 189 | 49 |
| VINCRISTINE | 376 | 0.5% | 199 | 142 | 55 |
| BENDAMUSTINE | 342 | 1.7% | 172 | 140 | 42 |
| DEXAMETHASONE | 327 | 0.3% | 131 | 145 | 63 |
| FLUDARABINE | 319 | 1.4% | 176 | 116 | 23 |
| FINGOLIMOD | 315 | 0.4% | 25 | 177 | 47 |
| METHYLPREDNISOLONE | 251 | 0.4% | 87 | 155 | 50 |
| CYCLOSPORINE | 213 | 0.3% | 66 | 91 | 7 |
| AZATHIOPRINE | 202 | 0.6% | 66 | 76 | 9 |
| LENALIDOMIDE | 202 | 0.1% | 96 | 85 | 42 |
| ETOPOSIDE | 201 | 0.4% | 119 | 74 | 36 |
| ETANERCEPT | 170 | 0.1% | 17 | 39 | 16 |