Does METHOTREXATE Cause Restless legs syndrome? 141 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 141 reports of Restless legs syndrome have been filed in association with METHOTREXATE (Methotrexate). This represents 0.1% of all adverse event reports for METHOTREXATE.
141
Reports of Restless legs syndrome with METHOTREXATE
0.1%
of all METHOTREXATE reports
1
Deaths
57
Hospitalizations
How Dangerous Is Restless legs syndrome From METHOTREXATE?
Of the 141 reports, 1 (0.7%) resulted in death, 57 (40.4%) required hospitalization, and 5 (3.5%) were considered life-threatening.
Is Restless legs syndrome Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for METHOTREXATE. However, 141 reports have been filed with the FAERS database.
What Other Side Effects Does METHOTREXATE Cause?
Drug ineffective (70,142)
Rheumatoid arthritis (29,254)
Off label use (24,020)
Pain (23,773)
Drug intolerance (22,555)
Arthralgia (21,831)
Fatigue (19,885)
Nausea (18,715)
Joint swelling (17,657)
Drug hypersensitivity (16,677)
What Other Drugs Cause Restless legs syndrome?
SODIUM OXYBATE (575)
QUETIAPINE (514)
MIRTAZAPINE (342)
PREGABALIN (329)
PRAMIPEXOLE (326)
ARIPIPRAZOLE (308)
ADALIMUMAB (280)
GABAPENTIN (263)
SERTRALINE (255)
ROTIGOTINE (254)
Which METHOTREXATE Alternatives Have Lower Restless legs syndrome Risk?
METHOTREXATE vs METHOXSALEN
METHOTREXATE vs METHOXY POLYETHYLENE GLYCOL-EPOETIN BETA
METHOTREXATE vs METHYL ALCOHOL
METHOTREXATE vs METHYLCOBALAMIN
METHOTREXATE vs METHYLDOPA