Does METHOTREXATE Cause Skin hyperpigmentation? 142 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 142 reports of Skin hyperpigmentation have been filed in association with METHOTREXATE (Methotrexate). This represents 0.1% of all adverse event reports for METHOTREXATE.
142
Reports of Skin hyperpigmentation with METHOTREXATE
0.1%
of all METHOTREXATE reports
7
Deaths
37
Hospitalizations
How Dangerous Is Skin hyperpigmentation From METHOTREXATE?
Of the 142 reports, 7 (4.9%) resulted in death, 37 (26.1%) required hospitalization, and 7 (4.9%) were considered life-threatening.
Is Skin hyperpigmentation Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for METHOTREXATE. However, 142 reports have been filed with the FAERS database.
What Other Side Effects Does METHOTREXATE Cause?
Drug ineffective (70,142)
Rheumatoid arthritis (29,254)
Off label use (24,020)
Pain (23,773)
Drug intolerance (22,555)
Arthralgia (21,831)
Fatigue (19,885)
Nausea (18,715)
Joint swelling (17,657)
Drug hypersensitivity (16,677)
What Other Drugs Cause Skin hyperpigmentation?
ADAPALENE (2,811)
AVOBENZONE\OCTISALATE\OCTOCRYLENE (2,277)
BIMATOPROST (189)
AVOBENZONE\HOMOSALATE\OCTINOXATE\OCTISALATE\OXYBENZONE (182)
DUPILUMAB (177)
MINOCYCLINE (144)
LENALIDOMIDE (142)
CAPECITABINE (136)
COLLAGENASE CLOSTRIDIUM HISTOLYTICUM-AAES (120)
SECUKINUMAB (100)
Which METHOTREXATE Alternatives Have Lower Skin hyperpigmentation Risk?
METHOTREXATE vs METHOXSALEN
METHOTREXATE vs METHOXY POLYETHYLENE GLYCOL-EPOETIN BETA
METHOTREXATE vs METHYL ALCOHOL
METHOTREXATE vs METHYLCOBALAMIN
METHOTREXATE vs METHYLDOPA