Skin hyperpigmentation: Which Medications Cause It? (6,549 Reports Across 285 Drugs)
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Skin hyperpigmentation has been reported as an adverse event with 285 different drugs in the FDA's FAERS database, with 6,549 total reports. 88 of these reports resulted in death.The drugs most commonly associated with Skin hyperpigmentation are ADAPALENE, AVOBENZONE\OCTISALATE\OCTOCRYLENE, and BIMATOPROST.
6,549
Total Reports
285
Drugs Involved
88
Deaths
584
Hospitalizations
40.4 yrs
Average Patient Age
74.6% / 25.4%
Female / Male
Which Drugs Cause Skin hyperpigmentation Most Often?
| Drug | Reports | % of Drug Reports | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| ADAPALENE | 2,811 | 1.6% | 0 | 1 | 0 |
| AVOBENZONE\OCTISALATE\OCTOCRYLENE | 2,277 | 1.7% | 0 | 1 | 0 |
| BIMATOPROST | 189 | 1.3% | 0 | 0 | 0 |
| AVOBENZONE\HOMOSALATE\OCTINOXATE\OCTISALATE\OXYBENZONE | 182 | 1.7% | 0 | 0 | 0 |
| DUPILUMAB | 177 | 0.1% | 0 | 3 | 0 |
| MINOCYCLINE | 144 | 2.2% | 0 | 9 | 1 |
| LENALIDOMIDE | 142 | 0.0% | 1 | 10 | 0 |
| METHOTREXATE | 142 | 0.1% | 7 | 37 | 7 |
| CAPECITABINE | 136 | 0.2% | 6 | 13 | 3 |
| COLLAGENASE CLOSTRIDIUM HISTOLYTICUM-AAES | 120 | 10.2% | 0 | 0 | 0 |
| SECUKINUMAB | 100 | 0.1% | 0 | 4 | 0 |
| MINOCYCLINE\MINOCYCLINE | 73 | 4.9% | 0 | 7 | 0 |
| BEVACIZUMAB | 63 | 0.1% | 9 | 17 | 1 |
| PREDNISONE | 62 | 0.0% | 1 | 5 | 1 |
| CYCLOSPORINE | 61 | 0.1% | 3 | 4 | 0 |
| PREDNISOLONE | 59 | 0.1% | 3 | 16 | 6 |
| CLOBETASOL | 58 | 0.7% | 0 | 10 | 1 |
| ADALIMUMAB | 56 | 0.0% | 0 | 9 | 0 |
| CLOFAZIMINE | 54 | 1.2% | 3 | 10 | 1 |
| HYDROXYCHLOROQUINE | 54 | 0.1% | 6 | 9 | 2 |