Does METHOTREXATE Cause Underdose? 693 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 693 reports of Underdose have been filed in association with METHOTREXATE (Methotrexate). This represents 0.3% of all adverse event reports for METHOTREXATE.
693
Reports of Underdose with METHOTREXATE
0.3%
of all METHOTREXATE reports
321
Deaths
500
Hospitalizations
How Dangerous Is Underdose From METHOTREXATE?
Of the 693 reports, 321 (46.3%) resulted in death, 500 (72.2%) required hospitalization, and 380 (54.8%) were considered life-threatening.
Is Underdose Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for METHOTREXATE. However, 693 reports have been filed with the FAERS database.
What Other Side Effects Does METHOTREXATE Cause?
Drug ineffective (70,142)
Rheumatoid arthritis (29,254)
Off label use (24,020)
Pain (23,773)
Drug intolerance (22,555)
Arthralgia (21,831)
Fatigue (19,885)
Nausea (18,715)
Joint swelling (17,657)
Drug hypersensitivity (16,677)
What Other Drugs Cause Underdose?
ADAPALENE (5,192)
AVOBENZONE\OCTISALATE\OCTOCRYLENE (3,722)
INSULIN LISPRO (3,156)
ETANERCEPT (3,145)
GALCANEZUMAB-GNLM (2,909)
ENZALUTAMIDE (2,017)
FLUTICASONE\SALMETEROL (1,600)
ALBUTEROL (1,593)
EXENATIDE (1,571)
TROFINETIDE (1,540)
Which METHOTREXATE Alternatives Have Lower Underdose Risk?
METHOTREXATE vs METHOXSALEN
METHOTREXATE vs METHOXY POLYETHYLENE GLYCOL-EPOETIN BETA
METHOTREXATE vs METHYL ALCOHOL
METHOTREXATE vs METHYLCOBALAMIN
METHOTREXATE vs METHYLDOPA