Does PEGASPARGASE Cause Hypofibrinogenaemia? 296 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 296 reports of Hypofibrinogenaemia have been filed in association with PEGASPARGASE (ONCASPAR). This represents 2.6% of all adverse event reports for PEGASPARGASE.
296
Reports of Hypofibrinogenaemia with PEGASPARGASE
2.6%
of all PEGASPARGASE reports
5
Deaths
64
Hospitalizations
How Dangerous Is Hypofibrinogenaemia From PEGASPARGASE?
Of the 296 reports, 5 (1.7%) resulted in death, 64 (21.6%) required hospitalization, and 9 (3.0%) were considered life-threatening.
Is Hypofibrinogenaemia Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for PEGASPARGASE. However, 296 reports have been filed with the FAERS database.
What Other Side Effects Does PEGASPARGASE Cause?
Febrile neutropenia (1,589)
Pyrexia (706)
Febrile bone marrow aplasia (668)
Sepsis (548)
Vomiting (530)
Neutropenia (521)
Abdominal pain (469)
Hypertriglyceridaemia (399)
Hypotension (388)
Thrombocytopenia (382)
What Other Drugs Cause Hypofibrinogenaemia?
METHOTREXATE (297)
VINCRISTINE (295)
DAUNORUBICIN (186)
CYTARABINE (177)
DEXAMETHASONE (174)
HYDROCORTISONE (126)
PREDNISONE (124)
TOCILIZUMAB (121)
PREDNISOLONE (117)
TIGECYCLINE (88)
Which PEGASPARGASE Alternatives Have Lower Hypofibrinogenaemia Risk?
PEGASPARGASE vs PEGASYS
PEGASPARGASE vs PEGCETACOPLAN
PEGASPARGASE vs PEGFILGRASTIM
PEGASPARGASE vs PEGFILGRASTIM-APGF
PEGASPARGASE vs PEGFILGRASTIM-BMEZ