Does METHOTREXATE Cause Hypofibrinogenaemia? 297 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 297 reports of Hypofibrinogenaemia have been filed in association with METHOTREXATE (Methotrexate). This represents 0.1% of all adverse event reports for METHOTREXATE.
297
Reports of Hypofibrinogenaemia with METHOTREXATE
0.1%
of all METHOTREXATE reports
4
Deaths
63
Hospitalizations
How Dangerous Is Hypofibrinogenaemia From METHOTREXATE?
Of the 297 reports, 4 (1.3%) resulted in death, 63 (21.2%) required hospitalization, and 8 (2.7%) were considered life-threatening.
Is Hypofibrinogenaemia Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for METHOTREXATE. However, 297 reports have been filed with the FAERS database.
What Other Side Effects Does METHOTREXATE Cause?
Drug ineffective (70,142)
Rheumatoid arthritis (29,254)
Off label use (24,020)
Pain (23,773)
Drug intolerance (22,555)
Arthralgia (21,831)
Fatigue (19,885)
Nausea (18,715)
Joint swelling (17,657)
Drug hypersensitivity (16,677)
What Other Drugs Cause Hypofibrinogenaemia?
PEGASPARGASE (296)
VINCRISTINE (295)
DAUNORUBICIN (186)
CYTARABINE (177)
DEXAMETHASONE (174)
HYDROCORTISONE (126)
PREDNISONE (124)
TOCILIZUMAB (121)
PREDNISOLONE (117)
TIGECYCLINE (88)
Which METHOTREXATE Alternatives Have Lower Hypofibrinogenaemia Risk?
METHOTREXATE vs METHOXSALEN
METHOTREXATE vs METHOXY POLYETHYLENE GLYCOL-EPOETIN BETA
METHOTREXATE vs METHYL ALCOHOL
METHOTREXATE vs METHYLCOBALAMIN
METHOTREXATE vs METHYLDOPA