Does PEMBROLIZUMAB Cause Intestinal perforation? 220 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 220 reports of Intestinal perforation have been filed in association with PEMBROLIZUMAB (KEYTRUDA). This represents 0.3% of all adverse event reports for PEMBROLIZUMAB.
220
Reports of Intestinal perforation with PEMBROLIZUMAB
0.3%
of all PEMBROLIZUMAB reports
55
Deaths
126
Hospitalizations
How Dangerous Is Intestinal perforation From PEMBROLIZUMAB?
Of the 220 reports, 55 (25.0%) resulted in death, 126 (57.3%) required hospitalization, and 33 (15.0%) were considered life-threatening.
Is Intestinal perforation Listed in the Official Label?
Yes, Intestinal perforation is listed as a known adverse reaction in the official FDA drug label for PEMBROLIZUMAB.
What Other Side Effects Does PEMBROLIZUMAB Cause?
Malignant neoplasm progression (10,111)
Death (4,744)
Diarrhoea (4,251)
Fatigue (3,833)
Off label use (3,416)
Product use in unapproved indication (3,191)
Pyrexia (3,155)
Rash (2,900)
Nausea (2,670)
Decreased appetite (2,486)
What Other Drugs Cause Intestinal perforation?
ADALIMUMAB (1,010)
BEVACIZUMAB (600)
RITUXIMAB (321)
TOCILIZUMAB (276)
PREDNISONE (266)
CYCLOPHOSPHAMIDE (262)
DOXORUBICIN (240)
LENVATINIB (228)
INFLIXIMAB (226)
METHOTREXATE (202)
Which PEMBROLIZUMAB Alternatives Have Lower Intestinal perforation Risk?
PEMBROLIZUMAB vs PEMETREXED
PEMBROLIZUMAB vs PEMIGATINIB
PEMBROLIZUMAB vs PENICILLAMINE
PEMBROLIZUMAB vs PENICILLIN
PEMBROLIZUMAB vs PENICILLIN G