Intestinal perforation: Which Medications Cause It? (7,751 Reports Across 386 Drugs)
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Intestinal perforation has been reported as an adverse event with 386 different drugs in the FDA's FAERS database, with 7,751 total reports. 2,004 of these reports resulted in death.The drugs most commonly associated with Intestinal perforation are ADALIMUMAB, BEVACIZUMAB, and RITUXIMAB.
7,751
Total Reports
386
Drugs Involved
2,004
Deaths
4,696
Hospitalizations
57.1 yrs
Average Patient Age
55.2% / 44.8%
Female / Male
Which Drugs Cause Intestinal perforation Most Often?
| Drug | Reports | % of Drug Reports | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| ADALIMUMAB | 1,010 | 0.2% | 76 | 638 | 31 |
| BEVACIZUMAB | 600 | 0.8% | 236 | 239 | 91 |
| RITUXIMAB | 321 | 0.2% | 98 | 161 | 44 |
| TOCILIZUMAB | 276 | 0.3% | 29 | 157 | 38 |
| PREDNISONE | 266 | 0.2% | 76 | 147 | 26 |
| CYCLOPHOSPHAMIDE | 262 | 0.2% | 106 | 148 | 44 |
| DOXORUBICIN | 240 | 0.3% | 86 | 112 | 32 |
| LENVATINIB | 228 | 0.7% | 47 | 151 | 25 |
| INFLIXIMAB | 226 | 0.2% | 25 | 134 | 11 |
| PEMBROLIZUMAB | 220 | 0.3% | 55 | 126 | 33 |
| METHOTREXATE | 202 | 0.1% | 23 | 110 | 23 |
| PACLITAXEL | 191 | 0.3% | 102 | 99 | 41 |
| VINCRISTINE | 191 | 0.3% | 72 | 108 | 22 |
| DEXAMETHASONE | 179 | 0.1% | 60 | 121 | 42 |
| CARBOPLATIN | 175 | 0.2% | 84 | 79 | 36 |
| FLUOROURACIL | 175 | 0.3% | 54 | 78 | 34 |
| OXALIPLATIN | 166 | 0.3% | 51 | 66 | 31 |
| IPILIMUMAB | 157 | 0.4% | 69 | 103 | 32 |
| NIVOLUMAB | 157 | 0.2% | 68 | 86 | 35 |
| METHYLPREDNISOLONE | 153 | 0.2% | 26 | 99 | 29 |