Does NIVOLUMAB Cause Intestinal perforation? 157 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 157 reports of Intestinal perforation have been filed in association with NIVOLUMAB (OPDIVO). This represents 0.2% of all adverse event reports for NIVOLUMAB.
157
Reports of Intestinal perforation with NIVOLUMAB
0.2%
of all NIVOLUMAB reports
68
Deaths
86
Hospitalizations
How Dangerous Is Intestinal perforation From NIVOLUMAB?
Of the 157 reports, 68 (43.3%) resulted in death, 86 (54.8%) required hospitalization, and 35 (22.3%) were considered life-threatening.
Is Intestinal perforation Listed in the Official Label?
Yes, Intestinal perforation is listed as a known adverse reaction in the official FDA drug label for NIVOLUMAB.
What Other Side Effects Does NIVOLUMAB Cause?
Death (11,216)
Malignant neoplasm progression (9,363)
Off label use (5,208)
Diarrhoea (4,692)
Fatigue (3,709)
Pyrexia (3,454)
Intentional product use issue (3,297)
Rash (2,816)
Nausea (2,805)
Decreased appetite (2,619)
What Other Drugs Cause Intestinal perforation?
ADALIMUMAB (1,010)
BEVACIZUMAB (600)
RITUXIMAB (321)
TOCILIZUMAB (276)
PREDNISONE (266)
CYCLOPHOSPHAMIDE (262)
DOXORUBICIN (240)
LENVATINIB (228)
INFLIXIMAB (226)
PEMBROLIZUMAB (220)
Which NIVOLUMAB Alternatives Have Lower Intestinal perforation Risk?
NIVOLUMAB vs NIVOLUMAB\RELATLIMAB-RMBW
NIVOLUMAB vs NIZATIDINE
NIVOLUMAB vs NOMEGESTROL
NIVOLUMAB vs NORDAZEPAM
NIVOLUMAB vs NOREPINEPHRINE