Does PEMETREXED Cause Agranulocytosis? 98 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 98 reports of Agranulocytosis have been filed in association with PEMETREXED (Pemetrexed). This represents 0.4% of all adverse event reports for PEMETREXED.
98
Reports of Agranulocytosis with PEMETREXED
0.4%
of all PEMETREXED reports
12
Deaths
79
Hospitalizations
How Dangerous Is Agranulocytosis From PEMETREXED?
Of the 98 reports, 12 (12.2%) resulted in death, 79 (80.6%) required hospitalization, and 27 (27.6%) were considered life-threatening.
Is Agranulocytosis Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for PEMETREXED. However, 98 reports have been filed with the FAERS database.
What Other Side Effects Does PEMETREXED Cause?
Malignant neoplasm progression (2,149)
Off label use (1,663)
Anaemia (1,430)
Pancytopenia (1,236)
Neutropenia (1,200)
Nausea (1,195)
Diarrhoea (1,165)
Acute kidney injury (1,105)
Thrombocytopenia (1,059)
Disease progression (969)
What Other Drugs Cause Agranulocytosis?
CLOZAPINE (1,766)
CYCLOPHOSPHAMIDE (1,242)
RITUXIMAB (1,154)
SULFAMETHOXAZOLE\TRIMETHOPRIM (797)
PANTOPRAZOLE (599)
METHOTREXATE (550)
SODIUM (549)
EPIRUBICIN (491)
METAMIZOLE (438)
DOCETAXEL (436)
Which PEMETREXED Alternatives Have Lower Agranulocytosis Risk?
PEMETREXED vs PEMIGATINIB
PEMETREXED vs PENICILLAMINE
PEMETREXED vs PENICILLIN
PEMETREXED vs PENICILLIN G
PEMETREXED vs PENICILLIN G BENZATHINE