Does PYRAZINAMIDE Cause Splenomegaly? 20 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 20 reports of Splenomegaly have been filed in association with PYRAZINAMIDE (Pyrazinamide). This represents 0.4% of all adverse event reports for PYRAZINAMIDE.
20
Reports of Splenomegaly with PYRAZINAMIDE
0.4%
of all PYRAZINAMIDE reports
15
Deaths
17
Hospitalizations
How Dangerous Is Splenomegaly From PYRAZINAMIDE?
Of the 20 reports, 15 (75.0%) resulted in death, 17 (85.0%) required hospitalization, and 12 (60.0%) were considered life-threatening.
Is Splenomegaly Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for PYRAZINAMIDE. However, 20 reports have been filed with the FAERS database.
What Other Side Effects Does PYRAZINAMIDE Cause?
Drug-induced liver injury (588)
Drug reaction with eosinophilia and systemic symptoms (492)
Paradoxical drug reaction (407)
Vomiting (307)
Pyrexia (301)
Drug ineffective (298)
Off label use (288)
Hepatotoxicity (279)
Drug resistance (269)
Nausea (251)
What Other Drugs Cause Splenomegaly?
RUXOLITINIB (1,995)
RITUXIMAB (326)
PREDNISONE (299)
IBRUTINIB (279)
CYCLOPHOSPHAMIDE (254)
METHOTREXATE (253)
OXALIPLATIN (253)
ADALIMUMAB (245)
TACROLIMUS (218)
IMATINIB (216)
Which PYRAZINAMIDE Alternatives Have Lower Splenomegaly Risk?
PYRAZINAMIDE vs PYRIDOSTIGMINE
PYRAZINAMIDE vs PYRIDOXINE
PYRAZINAMIDE vs PYRIDOXINE\THIAMINE
PYRAZINAMIDE vs PYRIMETHAMINE
PYRAZINAMIDE vs PYROTINIB