Does METHOTREXATE Cause Splenomegaly? 253 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 253 reports of Splenomegaly have been filed in association with METHOTREXATE (Methotrexate). This represents 0.1% of all adverse event reports for METHOTREXATE.
253
Reports of Splenomegaly with METHOTREXATE
0.1%
of all METHOTREXATE reports
32
Deaths
144
Hospitalizations
How Dangerous Is Splenomegaly From METHOTREXATE?
Of the 253 reports, 32 (12.6%) resulted in death, 144 (56.9%) required hospitalization, and 27 (10.7%) were considered life-threatening.
Is Splenomegaly Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for METHOTREXATE. However, 253 reports have been filed with the FAERS database.
What Other Side Effects Does METHOTREXATE Cause?
Drug ineffective (70,142)
Rheumatoid arthritis (29,254)
Off label use (24,020)
Pain (23,773)
Drug intolerance (22,555)
Arthralgia (21,831)
Fatigue (19,885)
Nausea (18,715)
Joint swelling (17,657)
Drug hypersensitivity (16,677)
What Other Drugs Cause Splenomegaly?
RUXOLITINIB (1,995)
RITUXIMAB (326)
PREDNISONE (299)
IBRUTINIB (279)
CYCLOPHOSPHAMIDE (254)
OXALIPLATIN (253)
ADALIMUMAB (245)
TACROLIMUS (218)
IMATINIB (216)
VENETOCLAX (211)
Which METHOTREXATE Alternatives Have Lower Splenomegaly Risk?
METHOTREXATE vs METHOXSALEN
METHOTREXATE vs METHOXY POLYETHYLENE GLYCOL-EPOETIN BETA
METHOTREXATE vs METHYL ALCOHOL
METHOTREXATE vs METHYLCOBALAMIN
METHOTREXATE vs METHYLDOPA