Splenomegaly: Which Medications Cause It? (8,129 Reports Across 481 Drugs)
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Splenomegaly has been reported as an adverse event with 481 different drugs in the FDA's FAERS database, with 8,129 total reports. 1,296 of these reports resulted in death.The drugs most commonly associated with Splenomegaly are RUXOLITINIB, RITUXIMAB, and PREDNISONE.
8,129
Total Reports
481
Drugs Involved
1,296
Deaths
3,576
Hospitalizations
51.5 yrs
Average Patient Age
44.9% / 55.1%
Female / Male
Which Drugs Cause Splenomegaly Most Often?
| Drug | Reports | % of Drug Reports | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| RUXOLITINIB | 1,995 | 2.9% | 292 | 686 | 55 |
| RITUXIMAB | 326 | 0.2% | 80 | 107 | 14 |
| PREDNISONE | 299 | 0.2% | 79 | 128 | 24 |
| IBRUTINIB | 279 | 0.4% | 56 | 98 | 10 |
| CYCLOPHOSPHAMIDE | 254 | 0.2% | 72 | 103 | 40 |
| METHOTREXATE | 253 | 0.1% | 32 | 144 | 27 |
| OXALIPLATIN | 253 | 0.5% | 19 | 87 | 11 |
| ADALIMUMAB | 245 | 0.1% | 28 | 159 | 23 |
| TACROLIMUS | 218 | 0.2% | 74 | 122 | 34 |
| IMATINIB | 216 | 0.5% | 63 | 81 | 18 |
| VENETOCLAX | 211 | 0.4% | 72 | 91 | 3 |
| NILOTINIB | 207 | 0.9% | 34 | 111 | 9 |
| MYCOPHENOLATE MOFETIL | 187 | 0.3% | 63 | 84 | 23 |
| VINCRISTINE | 167 | 0.2% | 35 | 77 | 36 |
| PREDNISOLONE | 159 | 0.2% | 26 | 98 | 56 |
| DOXORUBICIN | 153 | 0.2% | 35 | 68 | 37 |
| HYDROXYUREA | 142 | 2.4% | 13 | 56 | 7 |
| CYCLOSPORINE | 141 | 0.2% | 68 | 63 | 8 |
| DEXAMETHASONE | 138 | 0.1% | 22 | 43 | 17 |
| ASPIRIN | 112 | 0.1% | 11 | 81 | 36 |