Does SIROLIMUS Cause Hepatotoxicity? 15 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 15 reports of Hepatotoxicity have been filed in association with SIROLIMUS (sirolimus). This represents 0.1% of all adverse event reports for SIROLIMUS.
15
Reports of Hepatotoxicity with SIROLIMUS
0.1%
of all SIROLIMUS reports
3
Deaths
4
Hospitalizations
How Dangerous Is Hepatotoxicity From SIROLIMUS?
Of the 15 reports, 3 (20.0%) resulted in death, 4 (26.7%) required hospitalization.
Is Hepatotoxicity Listed in the Official Label?
Yes, Hepatotoxicity is listed as a known adverse reaction in the official FDA drug label for SIROLIMUS.
What Other Side Effects Does SIROLIMUS Cause?
Off label use (1,960)
Drug ineffective (1,005)
Product use in unapproved indication (984)
Transplant rejection (698)
Pneumonia (599)
Product use issue (506)
Alopecia (491)
Acne (482)
Transplant dysfunction (468)
Condition aggravated (433)
What Other Drugs Cause Hepatotoxicity?
METHOTREXATE (1,917)
ACETAMINOPHEN (1,557)
LEFLUNOMIDE (829)
HYDROXYCHLOROQUINE (715)
PREDNISONE (707)
RITUXIMAB (702)
ETANERCEPT (699)
ADALIMUMAB (674)
CYCLOPHOSPHAMIDE (632)
SULFASALAZINE (613)
Which SIROLIMUS Alternatives Have Lower Hepatotoxicity Risk?
SIROLIMUS vs SIRUKUMAB
SIROLIMUS vs SITAGLIPTIN
SIROLIMUS vs SOAP
SIROLIMUS vs SODIUM
SIROLIMUS vs SODIUM BICARBONATE