Does SOTORASIB Cause Hepatotoxicity? 91 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 91 reports of Hepatotoxicity have been filed in association with SOTORASIB (LUMAKRAS). This represents 3.1% of all adverse event reports for SOTORASIB.
91
Reports of Hepatotoxicity with SOTORASIB
3.1%
of all SOTORASIB reports
16
Deaths
16
Hospitalizations
How Dangerous Is Hepatotoxicity From SOTORASIB?
Of the 91 reports, 16 (17.6%) resulted in death, 16 (17.6%) required hospitalization, and 2 (2.2%) were considered life-threatening.
Is Hepatotoxicity Listed in the Official Label?
Yes, Hepatotoxicity is listed as a known adverse reaction in the official FDA drug label for SOTORASIB.
What Other Side Effects Does SOTORASIB Cause?
Non-small cell lung cancer (483)
Death (319)
Disease progression (314)
Diarrhoea (284)
Off label use (193)
Nausea (98)
Non-small cell lung cancer metastatic (93)
Fatigue (87)
Hepatic function abnormal (80)
Aspartate aminotransferase increased (71)
What Other Drugs Cause Hepatotoxicity?
METHOTREXATE (1,917)
ACETAMINOPHEN (1,557)
LEFLUNOMIDE (829)
HYDROXYCHLOROQUINE (715)
PREDNISONE (707)
RITUXIMAB (702)
ETANERCEPT (699)
ADALIMUMAB (674)
CYCLOPHOSPHAMIDE (632)
SULFASALAZINE (613)
Which SOTORASIB Alternatives Have Lower Hepatotoxicity Risk?
SOTORASIB vs SOTROVIMAB
SOTORASIB vs SOVALDI
SOTORASIB vs SOYBEAN OIL
SOTORASIB vs SPARSENTAN
SOTORASIB vs SPARTALIZUMAB