Does TRAMETINIB Cause Hepatotoxicity? 58 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 58 reports of Hepatotoxicity have been filed in association with TRAMETINIB. This represents 1.0% of all adverse event reports for TRAMETINIB.
58
Reports of Hepatotoxicity with TRAMETINIB
1.0%
of all TRAMETINIB reports
7
Deaths
15
Hospitalizations
How Dangerous Is Hepatotoxicity From TRAMETINIB?
Of the 58 reports, 7 (12.1%) resulted in death, 15 (25.9%) required hospitalization, and 11 (19.0%) were considered life-threatening.
Is Hepatotoxicity Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for TRAMETINIB. However, 58 reports have been filed with the FAERS database.
What Other Side Effects Does TRAMETINIB Cause?
Pyrexia (1,096)
Malignant neoplasm progression (807)
Product use in unapproved indication (349)
Diarrhoea (325)
Nausea (301)
Rash (290)
Vomiting (289)
Fatigue (269)
Death (240)
Chills (227)
What Other Drugs Cause Hepatotoxicity?
METHOTREXATE (1,917)
ACETAMINOPHEN (1,557)
LEFLUNOMIDE (829)
HYDROXYCHLOROQUINE (715)
PREDNISONE (707)
RITUXIMAB (702)
ETANERCEPT (699)
ADALIMUMAB (674)
CYCLOPHOSPHAMIDE (632)
SULFASALAZINE (613)
Which TRAMETINIB Alternatives Have Lower Hepatotoxicity Risk?
TRAMETINIB vs TRAMETINIB DIMETHYL SULFOXIDE
TRAMETINIB vs TRANDOLAPRIL
TRAMETINIB vs TRANDOLAPRIL\VERAPAMIL
TRAMETINIB vs TRANEXAMIC ACID
TRAMETINIB vs TRANYLCYPROMINE