Does VALPROIC ACID Cause Hepatotoxicity? 125 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 125 reports of Hepatotoxicity have been filed in association with VALPROIC ACID (Valproic Acid). This represents 0.6% of all adverse event reports for VALPROIC ACID.
125
Reports of Hepatotoxicity with VALPROIC ACID
0.6%
of all VALPROIC ACID reports
17
Deaths
60
Hospitalizations
How Dangerous Is Hepatotoxicity From VALPROIC ACID?
Of the 125 reports, 17 (13.6%) resulted in death, 60 (48.0%) required hospitalization, and 8 (6.4%) were considered life-threatening.
Is Hepatotoxicity Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for VALPROIC ACID. However, 125 reports have been filed with the FAERS database.
What Other Side Effects Does VALPROIC ACID Cause?
Drug ineffective (3,511)
Drug interaction (1,542)
Toxicity to various agents (1,517)
Off label use (1,503)
Seizure (1,335)
Foetal exposure during pregnancy (1,046)
Somnolence (831)
Completed suicide (723)
Overdose (691)
Condition aggravated (673)
What Other Drugs Cause Hepatotoxicity?
METHOTREXATE (1,917)
ACETAMINOPHEN (1,557)
LEFLUNOMIDE (829)
HYDROXYCHLOROQUINE (715)
PREDNISONE (707)
RITUXIMAB (702)
ETANERCEPT (699)
ADALIMUMAB (674)
CYCLOPHOSPHAMIDE (632)
SULFASALAZINE (613)
Which VALPROIC ACID Alternatives Have Lower Hepatotoxicity Risk?
VALPROIC ACID vs VALPROMIDE
VALPROIC ACID vs VALSARTAN
VALPROIC ACID vs VALTREX
VALPROIC ACID vs VAMOROLONE
VALPROIC ACID vs VANCOMYCIN