Application site irritation: Which Medications Cause It? (8,243 Reports Across 105 Drugs)
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Application site irritation has been reported as an adverse event with 105 different drugs in the FDA's FAERS database, with 8,243 total reports. 15 of these reports resulted in death.The drugs most commonly associated with Application site irritation are MINOXIDIL, BUPRENORPHINE, and ESTRADIOL.
8,243
Total Reports
105
Drugs Involved
15
Deaths
150
Hospitalizations
50.8 yrs
Average Patient Age
59.2% / 40.8%
Female / Male
Which Drugs Cause Application site irritation Most Often?
| Drug | Reports | % of Drug Reports | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| MINOXIDIL | 1,826 | 3.0% | 0 | 4 | 1 |
| BUPRENORPHINE | 921 | 1.1% | 0 | 2 | 2 |
| ESTRADIOL | 624 | 2.0% | 0 | 2 | 0 |
| NICOTINE | 539 | 1.7% | 0 | 2 | 0 |
| SUMATRIPTAN | 392 | 2.3% | 0 | 0 | 0 |
| TESTOSTERONE | 390 | 1.4% | 0 | 3 | 0 |
| ESTRADIOL\NORETHINDRONE | 341 | 8.0% | 0 | 0 | 0 |
| FENTANYL | 271 | 0.3% | 0 | 1 | 1 |
| METHYLPHENIDATE | 235 | 0.8% | 0 | 1 | 0 |
| ETHINYL ESTRADIOL\NORELGESTROMIN | 139 | 2.1% | 0 | 0 | 0 |
| CALCIUM\DEXTROSE\MAGNESIUM\SODIUM\SODIUM | 137 | 0.2% | 0 | 7 | 0 |
| LIDOCAINE | 116 | 0.5% | 0 | 1 | 0 |
| OXYBUTYNIN | 112 | 1.4% | 0 | 1 | 0 |
| MECHLORETHAMINE | 103 | 4.0% | 0 | 6 | 0 |
| DAYTRANA | 100 | 6.9% | 0 | 0 | 0 |
| CLONIDINE | 97 | 0.8% | 0 | 2 | 0 |
| ROTIGOTINE | 91 | 1.2% | 3 | 6 | 0 |
| RIVASTIGMINE | 71 | 0.8% | 2 | 9 | 1 |
| OXYTROL FOR WOMEN | 66 | 2.3% | 0 | 0 | 0 |
| CHLORHEXIDINE\ISOPROPYL ALCOHOL | 65 | 1.1% | 1 | 3 | 0 |