Drug tolerance increased: Which Medications Cause It? (575 Reports Across 45 Drugs)
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Drug tolerance increased has been reported as an adverse event with 45 different drugs in the FDA's FAERS database, with 575 total reports. 25 of these reports resulted in death.The drugs most commonly associated with Drug tolerance increased are OXYCODONE, MORPHINE, and ACETAMINOPHEN\OXYCODONE.
575
Total Reports
45
Drugs Involved
25
Deaths
92
Hospitalizations
47.5 yrs
Average Patient Age
47.6% / 52.4%
Female / Male
Which Drugs Cause Drug tolerance increased Most Often?
| Drug | Reports | % of Drug Reports | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| OXYCODONE | 180 | 0.1% | 15 | 36 | 4 |
| MORPHINE | 95 | 0.1% | 7 | 28 | 4 |
| ACETAMINOPHEN\OXYCODONE | 92 | 0.1% | 5 | 18 | 5 |
| ACETAMINOPHEN\HYDROCODONE | 87 | 0.1% | 3 | 19 | 5 |
| HYDROMORPHONE | 86 | 0.1% | 7 | 23 | 5 |
| ADALIMUMAB | 67 | 0.0% | 0 | 10 | 0 |
| TRAMADOL | 54 | 0.1% | 0 | 8 | 1 |
| FENTANYL | 45 | 0.1% | 4 | 10 | 0 |
| ALPRAZOLAM | 33 | 0.1% | 3 | 10 | 5 |
| DIAMORPHINE | 30 | 0.3% | 3 | 6 | 1 |
| ACETAMINOPHEN\OXYCODONE\OXYCODONE TEREPHTHALATE | 28 | 0.2% | 6 | 5 | 4 |
| HYDROCODONE | 24 | 0.1% | 2 | 4 | 4 |
| PREGABALIN | 24 | 0.0% | 1 | 5 | 0 |
| BUPRENORPHINE | 23 | 0.0% | 2 | 6 | 0 |
| GABAPENTIN | 19 | 0.0% | 0 | 2 | 0 |
| COCAINE | 17 | 0.1% | 1 | 8 | 1 |
| METHADONE | 17 | 0.1% | 2 | 6 | 0 |
| OXYMORPHONE | 15 | 0.0% | 2 | 0 | 0 |
| DIAZEPAM | 14 | 0.0% | 0 | 5 | 2 |
| CETIRIZINE | 13 | 0.0% | 0 | 0 | 0 |