Febrile bone marrow aplasia: Which Medications Cause It? (3,132 Reports Across 196 Drugs)
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Febrile bone marrow aplasia has been reported as an adverse event with 196 different drugs in the FDA's FAERS database, with 3,132 total reports. 515 of these reports resulted in death.The drugs most commonly associated with Febrile bone marrow aplasia are VINCRISTINE, METHOTREXATE, and CYCLOPHOSPHAMIDE.
3,132
Total Reports
196
Drugs Involved
515
Deaths
2,499
Hospitalizations
50.9 yrs
Average Patient Age
50.6% / 49.4%
Female / Male
Which Drugs Cause Febrile bone marrow aplasia Most Often?
| Drug | Reports | % of Drug Reports | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| VINCRISTINE | 912 | 1.3% | 48 | 794 | 91 |
| METHOTREXATE | 880 | 0.4% | 49 | 770 | 84 |
| CYCLOPHOSPHAMIDE | 839 | 0.7% | 84 | 717 | 112 |
| CYTARABINE | 733 | 1.7% | 31 | 640 | 68 |
| PEGASPARGASE | 668 | 5.8% | 3 | 632 | 26 |
| DOXORUBICIN | 623 | 0.8% | 58 | 521 | 103 |
| DEXAMETHASONE | 555 | 0.4% | 43 | 506 | 49 |
| CARBOPLATIN | 440 | 0.5% | 110 | 335 | 101 |
| ETOPOSIDE | 413 | 0.8% | 65 | 314 | 82 |
| HYDROCORTISONE | 379 | 1.5% | 1 | 349 | 19 |
| RITUXIMAB | 313 | 0.2% | 58 | 215 | 63 |
| MERCAPTOPURINE | 308 | 2.7% | 8 | 302 | 2 |
| PEMETREXED | 201 | 0.9% | 78 | 150 | 34 |
| PREDNISONE | 195 | 0.1% | 25 | 142 | 33 |
| PEMBROLIZUMAB | 191 | 0.2% | 31 | 169 | 24 |
| METHYLPREDNISOLONE | 142 | 0.2% | 9 | 131 | 18 |
| CISPLATIN | 136 | 0.3% | 23 | 106 | 29 |
| PACLITAXEL | 133 | 0.2% | 14 | 112 | 29 |
| IFOSFAMIDE | 129 | 0.8% | 17 | 108 | 17 |
| DAUNORUBICIN | 125 | 1.3% | 14 | 100 | 6 |