Freezing phenomenon: Which Medications Cause It? (3,093 Reports Across 50 Drugs)
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Freezing phenomenon has been reported as an adverse event with 50 different drugs in the FDA's FAERS database, with 3,093 total reports. 152 of these reports resulted in death.The drugs most commonly associated with Freezing phenomenon are CARBIDOPA\LEVODOPA, PIMAVANSERIN, and FOSCARBIDOPA\FOSLEVODOPA.
3,093
Total Reports
50
Drugs Involved
152
Deaths
1,308
Hospitalizations
69.9 yrs
Average Patient Age
40.1% / 59.9%
Female / Male
Which Drugs Cause Freezing phenomenon Most Often?
| Drug | Reports | % of Drug Reports | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| CARBIDOPA\LEVODOPA | 2,311 | 4.0% | 131 | 1,110 | 28 |
| PIMAVANSERIN | 143 | 0.3% | 12 | 25 | 0 |
| FOSCARBIDOPA\FOSLEVODOPA | 111 | 3.5% | 2 | 65 | 0 |
| APOMORPHINE | 102 | 1.3% | 4 | 12 | 0 |
| LEVODOPA | 87 | 1.3% | 1 | 18 | 0 |
| AMANTADINE | 83 | 1.6% | 0 | 28 | 0 |
| ISTRADEFYLLINE | 73 | 1.5% | 1 | 4 | 0 |
| CLOZAPINE | 65 | 0.1% | 2 | 36 | 0 |
| ROTIGOTINE | 61 | 0.8% | 0 | 13 | 0 |
| QUETIAPINE | 58 | 0.1% | 1 | 25 | 0 |
| PRAMIPEXOLE | 53 | 0.9% | 1 | 21 | 1 |
| OPICAPONE | 46 | 4.2% | 0 | 7 | 0 |
| ROPINIROLE | 46 | 1.1% | 1 | 19 | 0 |
| RIVASTIGMINE | 39 | 0.4% | 4 | 2 | 3 |
| DROXIDOPA | 37 | 0.2% | 1 | 5 | 0 |
| CARBIDOPA\ENTACAPONE\LEVODOPA | 34 | 1.4% | 0 | 9 | 0 |
| BENSERAZIDE\LEVODOPA | 29 | 1.4% | 0 | 13 | 0 |
| ENTACAPONE | 28 | 2.0% | 0 | 14 | 0 |
| SAFINAMIDE | 25 | 5.8% | 2 | 2 | 0 |
| RASAGILINE | 24 | 0.9% | 1 | 8 | 0 |