Generalised tonic-clonic seizure: Which Medications Cause It? (15,101 Reports Across 657 Drugs)
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Generalised tonic-clonic seizure has been reported as an adverse event with 657 different drugs in the FDA's FAERS database, with 15,101 total reports. 892 of these reports resulted in death.The drugs most commonly associated with Generalised tonic-clonic seizure are LEVETIRACETAM, LACOSAMIDE, and LAMOTRIGINE.
15,101
Total Reports
657
Drugs Involved
892
Deaths
8,535
Hospitalizations
39.9 yrs
Average Patient Age
55.9% / 44.1%
Female / Male
Which Drugs Cause Generalised tonic-clonic seizure Most Often?
| Drug | Reports | % of Drug Reports | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| LEVETIRACETAM | 2,276 | 3.6% | 55 | 688 | 114 |
| LACOSAMIDE | 918 | 4.3% | 29 | 314 | 66 |
| LAMOTRIGINE | 863 | 1.8% | 48 | 420 | 106 |
| BUPROPION | 686 | 1.9% | 55 | 572 | 184 |
| TRAMADOL | 496 | 0.7% | 23 | 335 | 85 |
| VENLAFAXINE | 427 | 0.9% | 43 | 376 | 204 |
| CARBAMAZEPINE | 377 | 1.5% | 22 | 184 | 41 |
| VALPROIC ACID | 351 | 1.8% | 15 | 122 | 31 |
| LIDOCAINE | 308 | 1.4% | 27 | 215 | 150 |
| PHENYTOIN | 307 | 2.1% | 26 | 161 | 19 |
| CLOZAPINE | 300 | 0.3% | 9 | 193 | 22 |
| QUETIAPINE | 280 | 0.4% | 10 | 225 | 76 |
| OLANZAPINE | 278 | 0.5% | 23 | 194 | 72 |
| TOPIRAMATE | 276 | 1.0% | 17 | 118 | 14 |
| CLOBAZAM | 269 | 2.5% | 14 | 82 | 7 |
| CANNABIDIOL | 265 | 1.5% | 4 | 70 | 2 |
| FLUOXETINE | 260 | 0.8% | 17 | 202 | 47 |
| BRIVARACETAM | 255 | 4.2% | 5 | 81 | 8 |
| METHOTREXATE | 247 | 0.1% | 45 | 150 | 35 |
| VALPROATE | 239 | 1.5% | 17 | 115 | 18 |