Immune-mediated hypophysitis: Which Medications Cause It? (338 Reports Across 16 Drugs)
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Immune-mediated hypophysitis has been reported as an adverse event with 16 different drugs in the FDA's FAERS database, with 338 total reports. 21 of these reports resulted in death.The drugs most commonly associated with Immune-mediated hypophysitis are NIVOLUMAB, PEMBROLIZUMAB, and IPILIMUMAB.
338
Total Reports
16
Drugs Involved
21
Deaths
183
Hospitalizations
61.2 yrs
Average Patient Age
49.7% / 50.3%
Female / Male
Which Drugs Cause Immune-mediated hypophysitis Most Often?
| Drug | Reports | % of Drug Reports | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| NIVOLUMAB | 171 | 0.2% | 9 | 101 | 33 |
| PEMBROLIZUMAB | 137 | 0.2% | 4 | 73 | 22 |
| IPILIMUMAB | 135 | 0.4% | 10 | 85 | 21 |
| CARBOPLATIN | 59 | 0.1% | 1 | 32 | 9 |
| PACLITAXEL | 42 | 0.1% | 0 | 19 | 8 |
| CYCLOPHOSPHAMIDE | 33 | 0.0% | 0 | 17 | 8 |
| EPIRUBICIN | 23 | 0.1% | 0 | 13 | 8 |
| DURVALUMAB | 14 | 0.1% | 3 | 6 | 3 |
| BEVACIZUMAB | 12 | 0.0% | 0 | 1 | 0 |
| DOXORUBICIN | 11 | 0.0% | 0 | 5 | 0 |
| LENVATINIB | 10 | 0.0% | 2 | 9 | 2 |
| NELVUTAMIG | 9 | 3.3% | 0 | 4 | 0 |
| PEMETREXED | 7 | 0.0% | 1 | 4 | 1 |
| ATEZOLIZUMAB | 6 | 0.0% | 0 | 1 | 0 |
| TISLELIZUMAB | 6 | 0.1% | 1 | 1 | 0 |
| TREMELIMUMAB\TREMELIMUMAB-ACTL | 6 | 0.5% | 2 | 3 | 1 |