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Important: This site presents data from the FDA Adverse Event Reporting System (FAERS). A report does not mean the drug caused the event. Full disclaimer.

Initial insomnia: Which Medications Cause It? (6,712 Reports Across 368 Drugs)

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Initial insomnia has been reported as an adverse event with 368 different drugs in the FDA's FAERS database, with 6,712 total reports. 99 of these reports resulted in death.The drugs most commonly associated with Initial insomnia are SODIUM OXYBATE, DUPILUMAB, and CARBIDOPA\LEVODOPA.

6,712
Total Reports
368
Drugs Involved
99
Deaths
893
Hospitalizations
50.8 yrs
Average Patient Age
63.4% / 36.6%
Female / Male

Which Drugs Cause Initial insomnia Most Often?

Drug Reports % of Drug Reports Deaths Hosp. Life-Threat.
SODIUM OXYBATE 787 1.3% 1 25 0
DUPILUMAB 495 0.1% 2 20 0
CARBIDOPA\LEVODOPA 219 0.4% 14 101 12
TASIMELTEON 153 2.7% 0 2 0
QUETIAPINE 132 0.2% 4 48 4
OCRELIZUMAB 119 0.2% 1 61 0
LEVOTHYROXINE 102 0.2% 0 22 2
ADALIMUMAB 98 0.0% 1 19 1
DALFAMPRIDINE 98 0.2% 0 14 0
NIRAPARIB 96 0.4% 0 12 4
ZOLPIDEM 88 0.4% 1 26 6
METHYLPHENIDATE 81 0.3% 0 4 0
PREGABALIN 80 0.1% 0 17 3
SUVOREXANT 78 0.8% 0 5 0
METHOTREXATE 75 0.0% 0 22 7
ARIPIPRAZOLE 67 0.1% 3 22 2
ENZALUTAMIDE 66 0.1% 1 6 0
AMPHETAMINE ASPARTATE\AMPHETAMINE\DEXTROAMPHETAMINE SACCHARATE\DEXTROAMPHETAMINE 64 0.4% 0 3 0
CYCLOPHOSPHAMIDE 64 0.1% 0 24 0
SACUBITRIL\VALSARTAN 64 0.1% 0 9 0

View all 368 drugs →

Top 3 Drugs Associated With Initial insomnia

787 reports
495 reports
219 reports

Related Side Effects

Drug ineffective (1,049,718) Off label use (762,782) Death (660,423) Fatigue (599,248) Nausea (562,301) Diarrhoea (491,550) Pain (471,975) Headache (460,069) Dyspnoea (409,496) Dizziness (352,922)