Ketoacidosis: Which Medications Cause It? (5,279 Reports Across 151 Drugs)
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Ketoacidosis has been reported as an adverse event with 151 different drugs in the FDA's FAERS database, with 5,279 total reports. 324 of these reports resulted in death.The drugs most commonly associated with Ketoacidosis are EMPAGLIFLOZIN, DAPAGLIFLOZIN, and METFORMIN.
5,279
Total Reports
151
Drugs Involved
324
Deaths
3,335
Hospitalizations
53.8 yrs
Average Patient Age
54.2% / 45.8%
Female / Male
Which Drugs Cause Ketoacidosis Most Often?
| Drug | Reports | % of Drug Reports | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| EMPAGLIFLOZIN | 1,411 | 3.8% | 57 | 969 | 416 |
| DAPAGLIFLOZIN | 803 | 3.8% | 30 | 471 | 168 |
| METFORMIN | 658 | 0.7% | 56 | 435 | 208 |
| CANAGLIFLOZIN | 641 | 2.6% | 11 | 272 | 71 |
| INSULIN GLARGINE | 231 | 0.2% | 3 | 184 | 10 |
| INSULIN LISPRO | 229 | 0.3% | 1 | 155 | 12 |
| EMPAGLIFLOZIN\METFORMIN | 139 | 5.6% | 2 | 105 | 31 |
| INSULIN ASPART | 123 | 0.6% | 0 | 86 | 8 |
| DULAGLUTIDE | 101 | 0.1% | 2 | 75 | 13 |
| SEMAGLUTIDE | 98 | 0.2% | 0 | 70 | 17 |
| DAPAGLIFLOZIN PROPANEDIOL\METFORMIN | 96 | 4.3% | 2 | 61 | 31 |
| DAPAGLIFLOZIN PROPANEDIOL | 95 | 0.6% | 5 | 58 | 16 |
| INSULIN HUMAN | 90 | 0.3% | 1 | 66 | 4 |
| PEMBROLIZUMAB | 88 | 0.1% | 9 | 63 | 13 |
| TIRZEPATIDE | 80 | 0.1% | 3 | 60 | 11 |
| SITAGLIPTIN | 79 | 0.4% | 6 | 46 | 39 |
| NIVOLUMAB | 68 | 0.1% | 4 | 50 | 24 |
| OLANZAPINE | 55 | 0.1% | 16 | 21 | 19 |
| ALPELISIB | 45 | 0.5% | 6 | 27 | 4 |
| ARIPIPRAZOLE | 43 | 0.1% | 9 | 26 | 11 |