Metastases to central nervous system: Which Medications Cause It? (9,629 Reports Across 331 Drugs)
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Metastases to central nervous system has been reported as an adverse event with 331 different drugs in the FDA's FAERS database, with 9,629 total reports. 2,686 of these reports resulted in death.The drugs most commonly associated with Metastases to central nervous system are TRASTUZUMAB, CAPECITABINE, and OSIMERTINIB.
9,629
Total Reports
331
Drugs Involved
2,686
Deaths
2,830
Hospitalizations
57.7 yrs
Average Patient Age
62.1% / 37.9%
Female / Male
Which Drugs Cause Metastases to central nervous system Most Often?
| Drug | Reports | % of Drug Reports | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| TRASTUZUMAB | 1,180 | 2.5% | 179 | 171 | 25 |
| CAPECITABINE | 663 | 1.0% | 109 | 133 | 12 |
| OSIMERTINIB | 560 | 2.0% | 125 | 109 | 19 |
| PERTUZUMAB | 540 | 2.5% | 68 | 96 | 9 |
| PACLITAXEL | 498 | 0.6% | 106 | 111 | 17 |
| NIVOLUMAB | 495 | 0.6% | 139 | 246 | 33 |
| DABRAFENIB | 451 | 2.3% | 209 | 164 | 15 |
| CARBOPLATIN | 413 | 0.5% | 102 | 88 | 12 |
| DOCETAXEL | 410 | 0.6% | 85 | 102 | 17 |
| ADO-TRASTUZUMAB EMTANSINE | 386 | 4.4% | 45 | 84 | 8 |
| BEVACIZUMAB | 378 | 0.5% | 117 | 89 | 13 |
| GEFITINIB | 306 | 6.5% | 51 | 49 | 6 |
| DURVALUMAB | 294 | 1.7% | 36 | 46 | 5 |
| CYCLOPHOSPHAMIDE | 293 | 0.2% | 80 | 53 | 11 |
| TRAMETINIB DIMETHYL SULFOXIDE | 288 | 1.8% | 124 | 107 | 7 |
| TUCATINIB | 270 | 4.5% | 26 | 61 | 8 |
| FULVESTRANT | 260 | 1.5% | 39 | 80 | 6 |
| LETROZOLE | 254 | 0.8% | 58 | 55 | 8 |
| CISPLATIN | 252 | 0.5% | 67 | 50 | 9 |
| AFATINIB | 248 | 4.1% | 72 | 58 | 8 |