Microcephaly: Which Medications Cause It? (839 Reports Across 115 Drugs)
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Microcephaly has been reported as an adverse event with 115 different drugs in the FDA's FAERS database, with 839 total reports. 58 of these reports resulted in death.The drugs most commonly associated with Microcephaly are LAMOTRIGINE, VALPROATE, and METOPROLOL.
839
Total Reports
115
Drugs Involved
58
Deaths
130
Hospitalizations
12.6 yrs
Average Patient Age
58.7% / 41.3%
Female / Male
Which Drugs Cause Microcephaly Most Often?
| Drug | Reports | % of Drug Reports | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| LAMOTRIGINE | 74 | 0.2% | 6 | 15 | 3 |
| VALPROATE | 57 | 0.4% | 4 | 22 | 1 |
| METOPROLOL | 52 | 0.1% | 0 | 0 | 3 |
| LEVETIRACETAM | 46 | 0.1% | 3 | 1 | 0 |
| VENLAFAXINE | 42 | 0.1% | 1 | 2 | 0 |
| VALPROIC ACID | 38 | 0.2% | 3 | 10 | 0 |
| ACETAMINOPHEN | 37 | 0.0% | 0 | 3 | 0 |
| CARBAMAZEPINE | 36 | 0.2% | 3 | 1 | 0 |
| LEVOTHYROXINE | 34 | 0.1% | 0 | 3 | 0 |
| METFORMIN | 33 | 0.0% | 1 | 0 | 1 |
| SERTRALINE | 32 | 0.1% | 1 | 1 | 0 |
| METHOTREXATE | 26 | 0.0% | 1 | 1 | 0 |
| ESCITALOPRAM OXALATE | 25 | 0.1% | 1 | 0 | 0 |
| HYDROXYCHLOROQUINE | 25 | 0.0% | 2 | 1 | 1 |
| TOPIRAMATE | 25 | 0.1% | 0 | 1 | 0 |
| ARIPIPRAZOLE | 24 | 0.0% | 0 | 0 | 0 |
| PAROXETINE | 24 | 0.1% | 0 | 7 | 0 |
| QUETIAPINE | 24 | 0.0% | 1 | 1 | 0 |
| SUMATRIPTAN | 23 | 0.1% | 0 | 0 | 0 |
| VALSARTAN | 22 | 0.1% | 3 | 12 | 6 |