On and off phenomenon: Which Medications Cause It? (4,268 Reports Across 67 Drugs)
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On and off phenomenon has been reported as an adverse event with 67 different drugs in the FDA's FAERS database, with 4,268 total reports. 264 of these reports resulted in death.The drugs most commonly associated with On and off phenomenon are CARBIDOPA\LEVODOPA, FOSCARBIDOPA\FOSLEVODOPA, and PRAMIPEXOLE.
4,268
Total Reports
67
Drugs Involved
264
Deaths
2,191
Hospitalizations
69.4 yrs
Average Patient Age
42.2% / 57.8%
Female / Male
Which Drugs Cause On and off phenomenon Most Often?
| Drug | Reports | % of Drug Reports | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| CARBIDOPA\LEVODOPA | 3,509 | 6.0% | 241 | 1,887 | 63 |
| FOSCARBIDOPA\FOSLEVODOPA | 391 | 12.4% | 15 | 245 | 2 |
| PRAMIPEXOLE | 116 | 1.9% | 3 | 36 | 0 |
| APOMORPHINE | 107 | 1.3% | 1 | 21 | 0 |
| LEVODOPA | 106 | 1.6% | 4 | 26 | 0 |
| AMANTADINE | 81 | 1.6% | 2 | 40 | 0 |
| CLOZAPINE | 73 | 0.1% | 2 | 28 | 0 |
| ROPINIROLE | 72 | 1.7% | 3 | 30 | 0 |
| BENSERAZIDE\LEVODOPA | 65 | 3.2% | 0 | 47 | 4 |
| ENTACAPONE | 59 | 4.2% | 0 | 23 | 0 |
| ISTRADEFYLLINE | 58 | 1.2% | 1 | 3 | 0 |
| ROTIGOTINE | 55 | 0.7% | 0 | 30 | 0 |
| PIMAVANSERIN | 52 | 0.1% | 2 | 4 | 0 |
| RIVASTIGMINE | 51 | 0.6% | 3 | 13 | 3 |
| QUETIAPINE | 50 | 0.1% | 0 | 23 | 0 |
| CARBIDOPA\ENTACAPONE\LEVODOPA | 40 | 1.7% | 0 | 17 | 0 |
| RASAGILINE | 38 | 1.4% | 1 | 4 | 0 |
| MIRTAZAPINE | 32 | 0.1% | 0 | 20 | 0 |
| OPICAPONE | 25 | 2.3% | 1 | 6 | 0 |
| CLONAZEPAM | 20 | 0.1% | 0 | 6 | 0 |