Pyroglutamic acidosis: Which Medications Cause It? (345 Reports Across 17 Drugs)
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Pyroglutamic acidosis has been reported as an adverse event with 17 different drugs in the FDA's FAERS database, with 345 total reports. 32 of these reports resulted in death.The drugs most commonly associated with Pyroglutamic acidosis are ACETAMINOPHEN, FLUCLOXACILLIN, and ACETAMINOPHEN\HYDROCODONE.
345
Total Reports
17
Drugs Involved
32
Deaths
260
Hospitalizations
58.2 yrs
Average Patient Age
61.8% / 38.2%
Female / Male
Which Drugs Cause Pyroglutamic acidosis Most Often?
| Drug | Reports | % of Drug Reports | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| ACETAMINOPHEN | 305 | 0.2% | 30 | 225 | 51 |
| FLUCLOXACILLIN | 83 | 5.6% | 11 | 59 | 16 |
| ACETAMINOPHEN\HYDROCODONE | 30 | 0.0% | 1 | 29 | 7 |
| IBUPROFEN | 18 | 0.0% | 0 | 10 | 1 |
| VALPROIC ACID | 13 | 0.1% | 0 | 11 | 0 |
| CEFUROXIME | 11 | 0.2% | 9 | 3 | 0 |
| ACETAMINOPHEN\CODEINE | 8 | 0.1% | 0 | 7 | 0 |
| ADALIMUMAB | 8 | 0.0% | 0 | 8 | 0 |
| ACETAMINOPHEN\CODEINE\DOXYLAMINE | 7 | 13.5% | 0 | 5 | 0 |
| ALBUTEROL | 7 | 0.0% | 3 | 2 | 0 |
| PIPERACILLIN | 7 | 0.7% | 0 | 4 | 1 |
| TAZOBACTAM | 7 | 0.9% | 0 | 4 | 1 |
| VIGABATRIN | 7 | 0.1% | 0 | 5 | 2 |
| OXYCODONE | 6 | 0.0% | 0 | 4 | 2 |
| CODEINE | 5 | 0.0% | 0 | 4 | 0 |
| DICLOXACILLIN | 5 | 1.6% | 0 | 4 | 0 |
| PIPERACILLIN\TAZOBACTAM | 5 | 0.0% | 0 | 2 | 1 |