Systemic inflammatory response syndrome: Which Medications Cause It? (2,665 Reports Across 275 Drugs)
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Systemic inflammatory response syndrome has been reported as an adverse event with 275 different drugs in the FDA's FAERS database, with 2,665 total reports. 557 of these reports resulted in death.The drugs most commonly associated with Systemic inflammatory response syndrome are DOXORUBICIN, METHOTREXATE, and CYCLOPHOSPHAMIDE.
2,665
Total Reports
275
Drugs Involved
557
Deaths
1,927
Hospitalizations
53.5 yrs
Average Patient Age
50.5% / 49.5%
Female / Male
Which Drugs Cause Systemic inflammatory response syndrome Most Often?
| Drug | Reports | % of Drug Reports | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| DOXORUBICIN | 161 | 0.2% | 40 | 40 | 6 |
| METHOTREXATE | 158 | 0.1% | 40 | 95 | 30 |
| CYCLOPHOSPHAMIDE | 153 | 0.1% | 30 | 67 | 11 |
| CYTARABINE | 153 | 0.3% | 62 | 59 | 15 |
| METHYLPREDNISOLONE | 117 | 0.2% | 30 | 68 | 26 |
| ADALIMUMAB | 107 | 0.0% | 2 | 68 | 2 |
| RITUXIMAB | 106 | 0.1% | 34 | 40 | 14 |
| PREDNISOLONE | 99 | 0.1% | 35 | 49 | 7 |
| VINCRISTINE | 97 | 0.1% | 27 | 34 | 7 |
| MYCOPHENOLATE MOFETIL | 95 | 0.1% | 44 | 65 | 22 |
| PREDNISONE | 95 | 0.1% | 33 | 77 | 24 |
| DEXAMETHASONE | 83 | 0.1% | 16 | 45 | 12 |
| FLUDARABINE | 82 | 0.4% | 48 | 32 | 3 |
| INFLIXIMAB | 82 | 0.1% | 5 | 42 | 2 |
| LEVETIRACETAM | 78 | 0.1% | 0 | 30 | 11 |
| VANCOMYCIN | 76 | 0.2% | 46 | 46 | 13 |
| MIDAZOLAM | 75 | 0.7% | 0 | 35 | 0 |
| CARBOPLATIN | 70 | 0.1% | 14 | 57 | 14 |
| PROPOFOL | 69 | 0.4% | 1 | 24 | 3 |
| NIVOLUMAB | 65 | 0.1% | 10 | 58 | 18 |