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Important: This site presents data from the FDA Adverse Event Reporting System (FAERS). A report does not mean the drug caused the event. Full disclaimer.

Systemic scleroderma: Which Medications Cause It? (634 Reports Across 67 Drugs)

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Systemic scleroderma has been reported as an adverse event with 67 different drugs in the FDA's FAERS database, with 634 total reports. 111 of these reports resulted in death.The drugs most commonly associated with Systemic scleroderma are RITUXIMAB, CYCLOPHOSPHAMIDE, and MACITENTAN.

634
Total Reports
67
Drugs Involved
111
Deaths
223
Hospitalizations
57.6 yrs
Average Patient Age
72.3% / 27.7%
Female / Male

Which Drugs Cause Systemic scleroderma Most Often?

Drug Reports % of Drug Reports Deaths Hosp. Life-Threat.
RITUXIMAB 54 0.0% 1 26 0
CYCLOPHOSPHAMIDE 53 0.0% 10 22 6
MACITENTAN 52 0.1% 36 34 4
DOCETAXEL 49 0.1% 1 22 8
METHOTREXATE 45 0.0% 0 9 0
MYCOPHENOLATE MOFETIL 44 0.1% 2 16 0
FLUOROURACIL 34 0.1% 0 10 14
SELEXIPAG 34 0.2% 20 16 3
TREPROSTINIL 34 0.0% 12 12 0
BOSENTAN 30 0.2% 11 15 0
NINTEDANIB 29 0.1% 10 10 0
SILDENAFIL 25 0.1% 7 13 0
TADALAFIL 25 0.1% 11 11 3
EPIRUBICIN 24 0.2% 0 3 3
PEMBROLIZUMAB 23 0.0% 1 6 0
CARBOPLATIN 22 0.0% 3 18 0
PREDNISONE 22 0.0% 4 6 0
AMBRISENTAN 21 0.0% 4 4 0
PEMETREXED 20 0.1% 0 9 0
NIFEDIPINE 16 0.2% 0 1 0

View all 67 drugs →

Top 3 Drugs Associated With Systemic scleroderma

54 reports
53 reports
52 reports

Related Side Effects

Drug ineffective (1,049,718) Off label use (762,782) Death (660,423) Fatigue (599,248) Nausea (562,301) Diarrhoea (491,550) Pain (471,975) Headache (460,069) Dyspnoea (409,496) Dizziness (352,922)