Thyrotoxic crisis: Which Medications Cause It? (853 Reports Across 53 Drugs)
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Thyrotoxic crisis has been reported as an adverse event with 53 different drugs in the FDA's FAERS database, with 853 total reports. 96 of these reports resulted in death.The drugs most commonly associated with Thyrotoxic crisis are AMIODARONE, LEVOTHYROXINE, and METHIMAZOLE.
853
Total Reports
53
Drugs Involved
96
Deaths
577
Hospitalizations
50.8 yrs
Average Patient Age
63.6% / 36.4%
Female / Male
Which Drugs Cause Thyrotoxic crisis Most Often?
| Drug | Reports | % of Drug Reports | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| AMIODARONE | 180 | 0.7% | 49 | 137 | 57 |
| LEVOTHYROXINE | 142 | 0.2% | 0 | 85 | 28 |
| METHIMAZOLE | 75 | 3.0% | 6 | 53 | 23 |
| PEMBROLIZUMAB | 44 | 0.1% | 4 | 38 | 12 |
| IPILIMUMAB | 36 | 0.1% | 3 | 24 | 13 |
| NIVOLUMAB | 36 | 0.0% | 3 | 24 | 11 |
| PROPRANOLOL | 33 | 0.2% | 5 | 23 | 12 |
| PROPYLTHIOURACIL | 26 | 2.7% | 7 | 20 | 11 |
| LITHIUM | 23 | 0.2% | 0 | 18 | 3 |
| LENVATINIB | 22 | 0.1% | 0 | 19 | 0 |
| HYDROCORTISONE | 19 | 0.1% | 6 | 14 | 11 |
| AMPHETAMINE ASPARTATE\AMPHETAMINE\DEXTROAMPHETAMINE SACCHARATE\DEXTROAMPHETAMINE | 18 | 0.1% | 0 | 13 | 2 |
| ADALIMUMAB | 17 | 0.0% | 6 | 13 | 4 |
| PREDNISONE | 15 | 0.0% | 6 | 14 | 6 |
| ROCURONIUM | 15 | 0.2% | 0 | 9 | 2 |
| ALEMTUZUMAB | 14 | 0.1% | 0 | 11 | 3 |
| EPOPROSTENOL | 14 | 0.1% | 3 | 13 | 2 |
| QUETIAPINE | 14 | 0.0% | 1 | 13 | 8 |
| ETOMIDATE | 13 | 1.8% | 0 | 9 | 2 |
| CITALOPRAM HYDROBROMIDE | 12 | 0.0% | 0 | 12 | 7 |