Toxic encephalopathy: Which Medications Cause It? (3,761 Reports Across 256 Drugs)
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Toxic encephalopathy has been reported as an adverse event with 256 different drugs in the FDA's FAERS database, with 3,761 total reports. 327 of these reports resulted in death.The drugs most commonly associated with Toxic encephalopathy are METRONIDAZOLE, VALACYCLOVIR, and BACLOFEN.
3,761
Total Reports
256
Drugs Involved
327
Deaths
2,556
Hospitalizations
55.2 yrs
Average Patient Age
52.0% / 48.0%
Female / Male
Which Drugs Cause Toxic encephalopathy Most Often?
| Drug | Reports | % of Drug Reports | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| METRONIDAZOLE | 548 | 2.4% | 49 | 315 | 32 |
| VALACYCLOVIR | 384 | 2.9% | 20 | 292 | 30 |
| BACLOFEN | 182 | 0.7% | 1 | 136 | 22 |
| ACYCLOVIR | 168 | 1.2% | 5 | 114 | 14 |
| METHOTREXATE | 142 | 0.1% | 17 | 73 | 15 |
| METFORMIN | 137 | 0.2% | 0 | 111 | 6 |
| VALPROIC ACID | 124 | 0.6% | 1 | 81 | 13 |
| TACROLIMUS | 118 | 0.1% | 11 | 58 | 10 |
| IFOSFAMIDE | 116 | 0.7% | 14 | 56 | 6 |
| DIAZEPAM | 91 | 0.2% | 1 | 82 | 20 |
| PREGABALIN | 88 | 0.1% | 4 | 72 | 17 |
| LEVETIRACETAM | 87 | 0.1% | 0 | 38 | 4 |
| QUETIAPINE | 86 | 0.1% | 1 | 71 | 7 |
| CLONAZEPAM | 83 | 0.2% | 0 | 72 | 9 |
| CEFEPIME | 82 | 1.5% | 22 | 49 | 7 |
| MIDAZOLAM | 66 | 0.6% | 12 | 49 | 0 |
| ACETAMINOPHEN | 64 | 0.1% | 5 | 51 | 24 |
| FLUOROURACIL | 64 | 0.1% | 8 | 27 | 18 |
| DOXORUBICIN | 61 | 0.1% | 4 | 39 | 7 |
| FENTANYL | 61 | 0.1% | 3 | 55 | 4 |